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• W2321899894 abstract "You have accessJournal of UrologySexual Function/Dysfunction: Penis/Testis/Urethra: Benign Disease & Malignant Disease I1 Apr 2016PD34-08 IMMUNE PROFILING OF TESTICULAR GERM CELL TUMORS REVEALS HIGH EXPRESSION OF PD-L1 AND PD-1 Diana Taheri, Maria A Mendoza Rodriguez, Alcides Chaux, Charles Drake, Trinity J Bivalacqua, Alan Meeker, Janis Taube, Nilda Gonzalez-Roibon, William Nelson, Sirinivasan Yegnasubramanian, George Netto, and Michael Haffner Diana TaheriDiana Taheri More articles by this author , Maria A Mendoza RodriguezMaria A Mendoza Rodriguez More articles by this author , Alcides ChauxAlcides Chaux More articles by this author , Charles DrakeCharles Drake More articles by this author , Trinity J BivalacquaTrinity J Bivalacqua More articles by this author , Alan MeekerAlan Meeker More articles by this author , Janis TaubeJanis Taube More articles by this author , Nilda Gonzalez-RoibonNilda Gonzalez-Roibon More articles by this author , William NelsonWilliam Nelson More articles by this author , Sirinivasan YegnasubramanianSirinivasan Yegnasubramanian More articles by this author , George NettoGeorge Netto More articles by this author , and Michael HaffnerMichael Haffner More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.993AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Objective: Activation of the immunosuppressive PD-1/PD-L1 (programmed death ligand 1) pathway has been shown to be an important immune surveillance evasion mechanism in solid tumors. As demonstrated in recent phase III clinical trials, blockade of PD-1 signaling holds great promise for the treatment of a subset of solid tumors. Testicular germ cell tumors (TGCT) have been long recognized to harbor extensive lymphocytic infiltrates, suggesting a dominant role for immune editing in these lesions. Here we evaluated the tumor specific immune microenvironment in TGCTs to determine a potential utility for immune checkpoint blockade therapies in these tumors. METHODS Methods: Here we profiled the immune infiltrate in TGCT with particular focus on immune checkpoint and T-regulatory cell function. Using validated immunohistochemical stains for PD1 (anti-PD1 antibody “ab52587”), PDL-1 (Cell Signalling, E1L3N, 1:100), FOXP3 (eBioscience, 236A/E7, 1:250) and a double immunostain for CD8 and ki67 (Thermo Scientific, SP16, 1:900 and Invitrogen/Zymed 7B11, 1:900; respectively), applied to TMA sections, we evaluated a retrospectively collected cohort (1995-2008) of 98 TGCT comprised of 47 seminoma, 14 teratoma, 1 chorioncarcinoma, 13 yolksac tumors and 23 embryonal carcinoma. RESULTS Results: We found immunoreactivity for PD-1 and PD-L1 in 96/98 (94%) and 69/98 (70%) respectively. Notably, PD-L1 expression was predominantly found in infiltrating immune cells and was rarely detected in TGCT cells. Positivity for PD-1 correlated with the overall extends of immune infiltrate. FOXP3 positive cells were detected in 87/98 (88%) lesions and a positive correlation between the CD8 positive infiltrate and FOXP3 positive cells was observed. The extend of proliferating cells T-cells (as determined by CD8 and ki67 double positive immunoreactivity) was associated with PD1 expression (r = 0.41). CONCLUSIONS Conclusion: Here we provide the first in depth evaluation of the immune microenvironment of TGCTs and show that regulatory T-cell infiltrate and PD-1 and PD-L1 expression are common features in germ cell tumors. This observation suggests that therapeutic approaches involving immune checkpoint molecule blockade might be beneficial in patients with TGCT. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e841-e842 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Diana Taheri More articles by this author Maria A Mendoza Rodriguez More articles by this author Alcides Chaux More articles by this author Charles Drake More articles by this author Trinity J Bivalacqua More articles by this author Alan Meeker More articles by this author Janis Taube More articles by this author Nilda Gonzalez-Roibon More articles by this author William Nelson More articles by this author Sirinivasan Yegnasubramanian More articles by this author George Netto More articles by this author Michael Haffner More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2321899894 title "PD34-08 IMMUNE PROFILING OF TESTICULAR GERM CELL TUMORS REVEALS HIGH EXPRESSION OF PD-L1 AND PD-1" @default.
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