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- W2321934516 abstract "Oxidative processes have been suggested to play a major role in the development of Alzheimer's disease (AD). Antioxidants may prevent the onset of the disease as high dietary intake of vitamin C and E were reported to be associated with lower risk of AD. The goal of our study was to examine whether serum antioxidant levels (vitamin E, vitamin C, ß-carotene, lycopene and coenzyme Q10) are associated with dementia. Cross-sectional study, conducted from 2009–2010, of 232 aged individuals (mean age 80 years) in “The Activity and Function in the Ederly in Ulm” (ActiFE) study. The main outcome measure was cognitive impairment. We analyzed serum antioxidant level (vitamin C, vitamin E, ß-carotene, lycopene and coenzyme Q10) among 74 mildly demented compared to 158 age and gender matched controls by HPLC. Blood vitamin C and ß-carotene concentrations in blood were statistically significant lower in demented than in control persons even after adjustment for education, intake of dietary supplements, smoking habits, body mass index and alcohol consumption (3rd vs. 1st tertile: OR: 0.29, 95%CI, 0.09–0.96 and 0.13, 95%CI, 0.03–0.55, respectively). No associations were found for vitamin E, lycopene and coenzyme Q10. This study suggests an association of vitamin C and ß-carotene level in blood and dementia. However this is limited to the cross-sectional character of our study and longitudinal data will give further insight in this association." @default.
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- W2321934516 date "2012-07-01" @default.
- W2321934516 modified "2023-09-27" @default.
- W2321934516 title "P3-125: Association between antioxidant level in blood and dementia: A population-based cross-sectional case-control study" @default.
- W2321934516 doi "https://doi.org/10.1016/j.jalz.2012.05.1345" @default.
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