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• W2321937259 endingPage "5273" @default.
• W2321937259 startingPage "5270" @default.
• W2321937259 abstract "The first Pd(II)-catalyzed C–H addition to isatins by direct sp2/sp3 C–H bond activation for the construction of 3-substituted-3-hydroxy-2-oxindoles is reported. The bidentate nitrogen ligands were found to promote this reaction. Specifically, the preliminary bioassay indicated that 3-(5-chlorobenzoxazole)-3-hydroxy-N-benzyl-2-oxindole (2w) is a new inhibitor of human kidney cancer and hepatocellular carcinoma cells. Moreover, this reaction system exhibits great functional group tolerance and requires no directing group, extra base, or additives." @default.
• W2321937259 created "2016-06-24" @default.
• W2321937259 creator A5032811161 @default.
• W2321937259 creator A5042887043 @default.
• W2321937259 creator A5050404859 @default.
• W2321937259 creator A5051423100 @default.
• W2321937259 creator A5069233334 @default.
• W2321937259 date "2013-10-03" @default.
• W2321937259 modified "2023-10-17" @default.
• W2321937259 title "Palladium-Catalyzed <i>sp</i>² and <i>sp</i>³ C–H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles" @default.
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• W2321937259 doi "https://doi.org/10.1021/ol402494e" @default.

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