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• W2321938566 abstract "Hydrogen sulfide is produced endogenously in vascular tissue by cystathionine-gamma-lyase (CSE), and has both vasoregulatory and anti-oxidant effects. Little is known of H2S production or physiological role in cerebral vasculature, particularly in disease states such as diabetes, where there is increased oxidative stress. The aim was to examine the effect of diabetes on H2S production and function in rat middle cerebral arteries. Diabetes was induced with streptozotocin (50 mg/kg, iv). Middle cerebral artery (MCA) function was examined using myography and superoxide anion O2- generation measured using NADPH-dependent lucigenin-enhanced chemiluminescence. CSE mRNA expression was measured via qPCR. Diabetic rats had elevated blood glucose (p < 0.05) and significantly reduced MCA endothelial function (Relaxation to the endothelium-dependent dilator bradykinin (100 nM): Control: 48. ± 7% Diabetic: 30. ± 4%, n = 5, p < 0.05). Vasorelaxation to exogenous H2S was unaffected in diabetic MCA and was elicited via a combination of K+, Cl− and Ca2+ channel modulation. Vasorelaxation to the H2S precursor L-cysteine was significantly enhanced in diabetic MCA (%Rmax: Control: 83. ± 4 Diabetic: 97. ± 3 n = 7, p < 0.01). CSE mRNA was significantly elevated in diabetes (p < 0.05). MCA O2- production was increased in diabetes (O2- counts/mg (×103): Control: 14.6. ± 2.3, Diabetic: 43.0. ± 9.4, n = 9, p < 0.05). This increase was attenuated by incubation with exogenous H2S (25.8. ± 3.0, n = 9, p < 0.05). These data suggest that endogenous H2S production is upregulated in this model of diabetes. Vasorelaxation responses to exogenous H2S are preserved and exogenous H2S attenuates the enhanced MCA-generated O2- observed in the diabetic group. These data suggest that upregulation of endogenous H2S in diabetes may play a vasoprotective role." @default.
• W2321938566 created "2016-06-24" @default.
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• W2321938566 date "2014-05-01" @default.
• W2321938566 modified "2023-09-25" @default.
• W2321938566 title "P51 Effect of type 1 diabetes on the production and vasoactivity of hydrogen sulfide in rat middle cerebral arteries" @default.
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• W2321938566 doi "https://doi.org/10.1016/j.niox.2014.03.101" @default.
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