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• W2321985269 abstract "Unlike conventional photocoagulation, non-damaging retinal laser therapy (NRT) limits laser-induced heating to staybelow the retinal damage threshold and therefore requires careful dosimetry. Without the adverse effects associated withphotocoagulation, NRT can be applied to critical areas of the retina and repeatedly to manage chronic disorders. Althoughthe clinical benefits of NRT have been demonstrated, the mechanism of therapeutic effect and width of the therapeuticwindow below damage threshold are not well understood. Here, we measure activation of heat shock response via laser-inducedhyperthermia as one indication of cellular response. A 577 nm laser is used with the Endpoint Management (EpM)user interface, a titration algorithm, to set experimental pulse energies relative to a barely visible titration lesion. Live/deadstaining and histology show that the retinal damage threshold in rabbits is at 40% of titration energy on EpM scale. Heatshock protein 70 (HSP70) expression in the retinal pigment epithelium (RPE) was detected by whole-mountimmunohistochemistry after different levels of laser treatment. We show HSP70 expression in the RPE beginning at 25%of titration energy indicating that there is a window for NRT between 25% and 40% with activation of the heat shockprotein expression in response to hyperthermia. HSP70 expression is also seen at the perimeter of damaging lesions, asexpected based on a computational model of laser heating. Expression area for each pulse energy setting varied betweenlaser spots due to pigmentation changes, indicating the relatively narrow window of non-damaging activation andhighlighting the importance of proper titration." @default.
• W2321985269 created "2016-06-24" @default.
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• W2321985269 date "2016-03-04" @default.
• W2321985269 modified "2023-09-24" @default.
• W2321985269 title "Heat shock protein expression as guidance for the therapeutic window of retinal laser therapy" @default.
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• W2321985269 doi "https://doi.org/10.1117/12.2213171" @default.
• W2321985269 hasPublicationYear "2016" @default.
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