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• W2322010009 abstract "MicroRNAs (miRNAs) are an emerging class of biomarkers and therapeutic targets for various diseases including cancers. Here, we develop a homogeneous and label-free method for sensitive detection of let-7a miRNA based on bifunctional strand displacement amplification (SDA)-mediated hyperbranched rolling circle amplification (HRCA). The binding of target miRNA with the linear template initiates the bifunctional SDA reaction, generating two different kinds of triggers which can hybridize with the linear template to initiate new rounds of SDA reaction for the production of more and more triggers. In the meantime, the released two different kinds of triggers can function as the first and the second primers, respectively, to initiate the HRCA reaction whose products can be simply monitored by a standard fluorometer with SYBR Green I as the fluorescent indicator. The proposed method exhibits high sensitivity with a detection limit of as low as 1.8 × 10(-13) M and a large dynamic range of 5 orders of magnitude from 0.1 pM to 10 nM, and it can even discriminate the single-base difference among the miRNA family members. Moreover, this method can be used to analyze the total RNA samples from the human lung tissues and might be further applied for sensitive detection of various proteins, small molecules, and metal ions in combination with specific aptamers." @default.
• W2322010009 created "2016-06-24" @default.
• W2322010009 creator A5001568746 @default.
• W2322010009 creator A5059991955 @default.
• W2322010009 creator A5062026165 @default.
• W2322010009 date "2014-06-13" @default.
• W2322010009 modified "2023-09-25" @default.
• W2322010009 title "Homogeneous and Label-Free Detection of MicroRNAs Using Bifunctional Strand Displacement Amplification-Mediated Hyperbranched Rolling Circle Amplification" @default.
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• W2322010009 doi "https://doi.org/10.1021/ac501645x" @default.
• W2322010009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24903889" @default.
• W2322010009 hasPublicationYear "2014" @default.
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