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- W2322014595 abstract "This study aimed to evaluate both short-term and long-term outcomes over a 10-year period of a large cohort of consecutive patients with clinical stage I non-small cell lung cancer (NSCLC) that underwent either thoracoscopic (VATS-L) or open lobectomy (OPEN-L). Patients with c-stage I NSCLC without preoperative treatment were included. Univariable, multivariable and propensity-matched analyses were performed on an intention-to-treat basis. VATS-L was performed in 307 (32%) patients and OPEN-L in 656 (68%). Twenty-two (7%) patients underwent conversion to open. Fewer patients in the VATS-L group had pT2 tumours compared to the OPEN-L group (39% vs 48%, P = 0.012) and fewer patients had squamous cell carcinoma (26% vs 18%, P = 0.006). These differences resolved with propensity matching. VATS-L was associated with reduced overall and pulmonary morbidity, atrial arrhythmias, chest tube duration and hospitalization. Mortality was 0.3% and 1.4%, for VATS-L and OPEN-L groups (P = NS). In unmatched analysis 5-year survival favoured VATS-L (78% vs 68% P = 0.007), however, propensity matched analysis showed only a trend toward improved survival with VATS-L (78% vs 73% P = 0.071). Multivariable analysis revealed VATS-L (HR 0.64), male sex (HR 1.43), Zubrod performance status (HR 3.42), and increasing age (HR 1.04) to be independent predictors of survival. VATS lobectomy is associated with less perioperative morbidity compared to open lobectomy for clinical stage I NSCLC. There was a trend towards improved 5-year survival in the VATS-L group, which should be confirmed by larger prospective studies. D. Rice: Paid consultant for Olympus America, Inc. All other authors have declared no conflicts of interest." @default.
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- W2322014595 date "2013-07-01" @default.
- W2322014595 modified "2023-09-26" @default.
- W2322014595 title "F-104VIDEO-ASSISTED THORACOSCOPIC LOBECTOMY IS ASSOCIATED WITH IMPROVED SHORT-TERM AND LONG-TERM OUTCOMES COMPARED TO OPEN LOBECTOMY FOR C-STAGE I NON-SMALL CELL LUNG CANCER: A PROPENSITY-MATCHED ANALYSIS OF 963 CASES" @default.
- W2322014595 doi "https://doi.org/10.1093/icvts/ivt288.104" @default.
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