Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322127825> ?p ?o ?g. }
- W2322127825 abstract "Objective: Many interventions that exhibit therapeutic potential in preclinical Alzheimer’s disease (AD) research have not been proven effective clinically. One reason for this lack of translatability between animals and humans might be due to a failure to employ measures in animals that generalize to humans. The National Center for Toxicological Research (NCTR) has developed an operant test battery (OTB) designed to generate translational markers of complex brain function in rats, monkeys, and humans. The NCTR OTB has not, as yet, been used to assess cognitive function in persons with a diagnosis of AD. Thus, the purpose of this study was to assess the utility of the NCTR OTB to detect cognitive impairments in individuals with a diagnosis of AD. Methods: Seven participants with an AD diagnosis and 12 healthy adults (age ≥ 60), completed three operant tasks: Temporal Response Differentiation (TRD); Delayed Matching to Sample (DMTS); and Incremental Repeated Acquisition (IRA). These tasks were used to measure aspects of timing ability, short-term nonverbal memory and attention, and learning, respectively. Results: Persons with a diagnosis of Alzheimer’s disease performed significantly worse on all three tasks, displaying marked deficits in several areas of cognitive function. Conclusion: These results suggest that the NCTR OTB is capable of detecting cognitive impairments in individuals with AD and, therefore, is a useful tool for monitoring disease severity and progression and for screening compounds for cognitive enhancing effects in both preclinical and clinical research." @default.
- W2322127825 created "2016-06-24" @default.
- W2322127825 creator A5021110985 @default.
- W2322127825 creator A5059363633 @default.
- W2322127825 creator A5082772810 @default.
- W2322127825 creator A5084485087 @default.
- W2322127825 date "2016-01-01" @default.
- W2322127825 modified "2023-09-26" @default.
- W2322127825 title "The Use of Operant Tasks to Assess Cognition in Persons with Alzheimer’s Disease" @default.
- W2322127825 cites W1260726613 @default.
- W2322127825 cites W1637329562 @default.
- W2322127825 cites W1847168837 @default.
- W2322127825 cites W1953027527 @default.
- W2322127825 cites W1971327899 @default.
- W2322127825 cites W1973364745 @default.
- W2322127825 cites W1973488092 @default.
- W2322127825 cites W1975039425 @default.
- W2322127825 cites W1981165089 @default.
- W2322127825 cites W1982313782 @default.
- W2322127825 cites W1990790801 @default.
- W2322127825 cites W1991952617 @default.
- W2322127825 cites W2000901251 @default.
- W2322127825 cites W2003737825 @default.
- W2322127825 cites W2004802706 @default.
- W2322127825 cites W2006798950 @default.
- W2322127825 cites W2007557482 @default.
- W2322127825 cites W2007861486 @default.
- W2322127825 cites W2009282373 @default.
- W2322127825 cites W2013170196 @default.
- W2322127825 cites W2013302756 @default.
- W2322127825 cites W2013686447 @default.
- W2322127825 cites W2014314369 @default.
- W2322127825 cites W2018309041 @default.
- W2322127825 cites W2019461415 @default.
- W2322127825 cites W2020633891 @default.
- W2322127825 cites W2022502093 @default.
- W2322127825 cites W2026938853 @default.
- W2322127825 cites W2028223009 @default.
- W2322127825 cites W2032405644 @default.
- W2322127825 cites W2032709932 @default.
- W2322127825 cites W2033378076 @default.
- W2322127825 cites W2034467181 @default.
- W2322127825 cites W2038904039 @default.
- W2322127825 cites W2041731315 @default.
- W2322127825 cites W2054935086 @default.
- W2322127825 cites W2056728689 @default.
- W2322127825 cites W2060113175 @default.
- W2322127825 cites W2060977625 @default.
- W2322127825 cites W2061795541 @default.
- W2322127825 cites W2066350244 @default.
- W2322127825 cites W2067826421 @default.
- W2322127825 cites W2068892746 @default.
- W2322127825 cites W2074161297 @default.
- W2322127825 cites W2074358376 @default.
- W2322127825 cites W2075436449 @default.
- W2322127825 cites W2076627336 @default.
- W2322127825 cites W2076964290 @default.
- W2322127825 cites W2079234502 @default.
- W2322127825 cites W2082446434 @default.
- W2322127825 cites W2083003203 @default.
- W2322127825 cites W2084841026 @default.
- W2322127825 cites W2085745642 @default.
- W2322127825 cites W2092769993 @default.
- W2322127825 cites W2096693729 @default.
- W2322127825 cites W2108114788 @default.
- W2322127825 cites W2108149698 @default.
- W2322127825 cites W2109031511 @default.
- W2322127825 cites W2109140840 @default.
- W2322127825 cites W2121996461 @default.
- W2322127825 cites W2123979895 @default.
- W2322127825 cites W2125868297 @default.
- W2322127825 cites W2127963272 @default.
- W2322127825 cites W2128353777 @default.
- W2322127825 cites W2130256699 @default.
- W2322127825 cites W2134929864 @default.
- W2322127825 cites W2136250824 @default.
- W2322127825 cites W2138699752 @default.
- W2322127825 cites W2153869185 @default.
- W2322127825 cites W2156220037 @default.
- W2322127825 cites W2168813272 @default.
- W2322127825 cites W2168956721 @default.
- W2322127825 cites W2177752188 @default.
- W2322127825 cites W2209078744 @default.
- W2322127825 cites W2231470888 @default.
- W2322127825 cites W2272900632 @default.
- W2322127825 cites W2461390761 @default.
- W2322127825 cites W2462643239 @default.
- W2322127825 cites W2463288226 @default.
- W2322127825 cites W269853762 @default.
- W2322127825 cites W2799379448 @default.
- W2322127825 cites W40458340 @default.
- W2322127825 cites W595210553 @default.
- W2322127825 cites W618310327 @default.
- W2322127825 cites W8053701 @default.
- W2322127825 doi "https://doi.org/10.7726/ajad.2016.1001" @default.
- W2322127825 hasPublicationYear "2016" @default.
- W2322127825 type Work @default.
- W2322127825 sameAs 2322127825 @default.
- W2322127825 citedByCount "0" @default.
- W2322127825 crossrefType "journal-article" @default.