FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322134639> ?p ?o ?g. }

• W2322134639 endingPage "1318" @default.
• W2322134639 startingPage "1313" @default.
• W2322134639 abstract "The acid-labile inter-alpha-trypsin inhibitor is cleaved enzymatically in vivo, liberating a smaller acid-stable inhibitor. The molar ratio of native inhibitor to this smaller inhibitor in plasma is significantly changed in some severe cases of inflammation and kidney injury. To clarify this observation on a molecular basis, the action of four different types of proteinases (trypsin, plasmin, kallikrein and granulocyte elastase) on the inter-alpha-trypsin inhibitor was studied. The initial rate of cleavage of the inter-alpha-trypsin inhibitor by a 1.3-fold molar excess of proteinase over inhibitor was found to be 4375 nM x min-1 with granulocyte elastase, 860 nM x min-1 with trypsin, 67 nM x min-1 with plasmin, and 0.3 nM X min-1 with kallikrein. Obviously, of the enzymes studied so far, the granulocyte elastase known to be released during severe inflammatory processes is by far the most potent proteinase in the transformation of the inter-alpha-trypsin inhibitor. The inter-alpha-trypsin inhibitor and its cleavage products inhibit bovine trypsin very strongly (Ki = 10(-9)--10(-11) M), porcine plasmin much less strongly, human plasmin very weakly and pancreatic kallikrein practically not at all." @default.
• W2322134639 created "2016-06-24" @default.
• W2322134639 creator A5006739406 @default.
• W2322134639 creator A5037231293 @default.
• W2322134639 creator A5089923929 @default.
• W2322134639 date "1979-01-01" @default.
• W2322134639 modified "2023-09-23" @default.
• W2322134639 title "Human Inter-α-Trypsin Inhibitor. Limited Proteolysis by Trypsin, Plasmin, Kallikrein and Granulocytic Elastase and Inhibitory Properties of the Cleavage Products" @default.
• W2322134639 cites W2029417043 @default.
• W2322134639 cites W2317244174 @default.
• W2322134639 cites W2323656635 @default.
• W2322134639 cites W2327781251 @default.
• W2322134639 cites W2328761689 @default.
• W2322134639 cites W2330187798 @default.
• W2322134639 cites W2332177993 @default.
• W2322134639 cites W2425036209 @default.
• W2322134639 cites W2467479590 @default.
• W2322134639 cites W2914364695 @default.
• W2322134639 doi "https://doi.org/10.1515/bchm2.1979.360.2.1313" @default.
• W2322134639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/92450" @default.
• W2322134639 hasPublicationYear "1979" @default.
• W2322134639 type Work @default.
• W2322134639 sameAs 2322134639 @default.
• W2322134639 citedByCount "56" @default.
• W2322134639 crossrefType "journal-article" @default.
• W2322134639 hasAuthorship W2322134639A5006739406 @default.
• W2322134639 hasAuthorship W2322134639A5037231293 @default.
• W2322134639 hasAuthorship W2322134639A5089923929 @default.
• W2322134639 hasConcept C141814087 @default.
• W2322134639 hasConcept C142462285 @default.
• W2322134639 hasConcept C151730666 @default.
• W2322134639 hasConcept C153911025 @default.
• W2322134639 hasConcept C175156509 @default.
• W2322134639 hasConcept C181199279 @default.
• W2322134639 hasConcept C185592680 @default.
• W2322134639 hasConcept C203014093 @default.
• W2322134639 hasConcept C2776326425 @default.
• W2322134639 hasConcept C2776351012 @default.
• W2322134639 hasConcept C2776714187 @default.
• W2322134639 hasConcept C2776980637 @default.
• W2322134639 hasConcept C2777983669 @default.
• W2322134639 hasConcept C2780340462 @default.
• W2322134639 hasConcept C2781044401 @default.
• W2322134639 hasConcept C2781054842 @default.
• W2322134639 hasConcept C2781071845 @default.
• W2322134639 hasConcept C2781143361 @default.
• W2322134639 hasConcept C2781307694 @default.
• W2322134639 hasConcept C2993143319 @default.
• W2322134639 hasConcept C3013748606 @default.
• W2322134639 hasConcept C43369102 @default.
• W2322134639 hasConcept C52543561 @default.
• W2322134639 hasConcept C52853521 @default.
• W2322134639 hasConcept C55493867 @default.
• W2322134639 hasConcept C86803240 @default.
• W2322134639 hasConceptScore W2322134639C141814087 @default.
• W2322134639 hasConceptScore W2322134639C142462285 @default.
• W2322134639 hasConceptScore W2322134639C151730666 @default.
• W2322134639 hasConceptScore W2322134639C153911025 @default.
• W2322134639 hasConceptScore W2322134639C175156509 @default.
• W2322134639 hasConceptScore W2322134639C181199279 @default.
• W2322134639 hasConceptScore W2322134639C185592680 @default.
• W2322134639 hasConceptScore W2322134639C203014093 @default.
• W2322134639 hasConceptScore W2322134639C2776326425 @default.
• W2322134639 hasConceptScore W2322134639C2776351012 @default.
• W2322134639 hasConceptScore W2322134639C2776714187 @default.
• W2322134639 hasConceptScore W2322134639C2776980637 @default.
• W2322134639 hasConceptScore W2322134639C2777983669 @default.
• W2322134639 hasConceptScore W2322134639C2780340462 @default.
• W2322134639 hasConceptScore W2322134639C2781044401 @default.
• W2322134639 hasConceptScore W2322134639C2781054842 @default.
• W2322134639 hasConceptScore W2322134639C2781071845 @default.
• W2322134639 hasConceptScore W2322134639C2781143361 @default.
• W2322134639 hasConceptScore W2322134639C2781307694 @default.
• W2322134639 hasConceptScore W2322134639C2993143319 @default.
• W2322134639 hasConceptScore W2322134639C3013748606 @default.
• W2322134639 hasConceptScore W2322134639C43369102 @default.
• W2322134639 hasConceptScore W2322134639C52543561 @default.
• W2322134639 hasConceptScore W2322134639C52853521 @default.
• W2322134639 hasConceptScore W2322134639C55493867 @default.
• W2322134639 hasConceptScore W2322134639C86803240 @default.
• W2322134639 hasIssue "2" @default.
• W2322134639 hasLocation W23221346391 @default.
• W2322134639 hasLocation W23221346392 @default.
• W2322134639 hasOpenAccess W2322134639 @default.
• W2322134639 hasPrimaryLocation W23221346391 @default.
• W2322134639 hasRelatedWork W1862074917 @default.
• W2322134639 hasRelatedWork W1893746232 @default.
• W2322134639 hasRelatedWork W1972306338 @default.
• W2322134639 hasRelatedWork W1982487785 @default.
• W2322134639 hasRelatedWork W2058029179 @default.
• W2322134639 hasRelatedWork W2317996428 @default.
• W2322134639 hasRelatedWork W2322134639 @default.
• W2322134639 hasRelatedWork W2322633798 @default.
• W2322134639 hasRelatedWork W2327992315 @default.
• W2322134639 hasRelatedWork W2462793456 @default.
• W2322134639 hasVolume "360" @default.
• W2322134639 isParatext "false" @default.
• W2322134639 isRetracted "false" @default.

• next