Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322152904> ?p ?o ?g. }
- W2322152904 abstract "We reviewed outcomes of patients with loco-regionally recurrent (LRR) or new primary (NP) squamous cell carcinoma of the head and neck (SCCHN) treated at our institution with reirradiation (RRT).Patients received definitive RRT (DRRT) or post-operative RRT following salvage surgery (PRRT) from 2003 to 2011. Measured survival outcomes included loco-regional relapse free survival (LRFS) and overall survival (OS).Among 81 patients (PRRT, 42; DRRT, 39), median PRRT and DRRT doses were 60 Gy (12-70 Gy) and 69.6 Gy (48-76.8 Gy). The majority of patients received IMRT-based RRT (n = 77, 95 %). With median follow-up of 78.1 months (95 % CI, 56-96.8 months), 2-year OS was 53 % with PRRT and 48 % with DRRT (p = 0.12); 23 % of patients were alive at last follow-up. LRFS at 2 years was 60 %, and did not differ significantly between PRRT and DRRT groups. A trend toward inferior LRFS was noted among patients receiving chemotherapy with RRT versus RRT alone (p = 0.06). Late serious toxicities were uncommon, including osteoradionecrosis (2 patients) and carotid artery bleeding (1 patient, non-fatal).OS of PRRT- and DRRT-treated patients in this series appears superior to the published literature. We used IMRT for the majority of patients, in contrast to several series and trials previously reported, which may account in part for this difference. Future studies should seek to improve outcomes among patients with LRR/NP SCCHN via alternative therapeutic modalities such as proton radiotherapy and by incorporating novel systemic agents." @default.
- W2322152904 created "2016-06-24" @default.
- W2322152904 creator A5002341560 @default.
- W2322152904 creator A5030089962 @default.
- W2322152904 creator A5038693643 @default.
- W2322152904 creator A5038981517 @default.
- W2322152904 creator A5039064680 @default.
- W2322152904 creator A5048589047 @default.
- W2322152904 creator A5060433852 @default.
- W2322152904 creator A5063880741 @default.
- W2322152904 creator A5083170859 @default.
- W2322152904 creator A5086970088 @default.
- W2322152904 creator A5090700846 @default.
- W2322152904 date "2016-04-09" @default.
- W2322152904 modified "2023-10-12" @default.
- W2322152904 title "Outcomes of patients with loco-regionally recurrent or new primary squamous cell carcinomas of the head and neck treated with curative intent reirradiation at Mayo Clinic" @default.
- W2322152904 cites W1238253458 @default.
- W2322152904 cites W1502611983 @default.
- W2322152904 cites W1513475588 @default.
- W2322152904 cites W1588042002 @default.
- W2322152904 cites W1919845303 @default.
- W2322152904 cites W1934897058 @default.
- W2322152904 cites W1966557662 @default.
- W2322152904 cites W1976104376 @default.
- W2322152904 cites W1981779825 @default.
- W2322152904 cites W1983930808 @default.
- W2322152904 cites W1992544851 @default.
- W2322152904 cites W2012794386 @default.
- W2322152904 cites W2019928139 @default.
- W2322152904 cites W2030389627 @default.
- W2322152904 cites W2038864978 @default.
- W2322152904 cites W2043453187 @default.
- W2322152904 cites W2046435071 @default.
- W2322152904 cites W2046441558 @default.
- W2322152904 cites W2052966384 @default.
- W2322152904 cites W2058984926 @default.
- W2322152904 cites W2061014005 @default.
- W2322152904 cites W2067551303 @default.
- W2322152904 cites W2069044148 @default.
- W2322152904 cites W2075738043 @default.
- W2322152904 cites W2081428711 @default.
- W2322152904 cites W2096560865 @default.
- W2322152904 cites W2097325383 @default.
- W2322152904 cites W2101041628 @default.
- W2322152904 cites W2103766773 @default.
- W2322152904 cites W2112511211 @default.
- W2322152904 cites W2117817889 @default.
- W2322152904 cites W2124654120 @default.
- W2322152904 cites W2131006261 @default.
- W2322152904 cites W2133472045 @default.
- W2322152904 cites W2142358588 @default.
- W2322152904 cites W2143490199 @default.
- W2322152904 cites W2143874948 @default.
- W2322152904 cites W2153439641 @default.
- W2322152904 cites W2157668359 @default.
- W2322152904 cites W2170552969 @default.
- W2322152904 cites W2172200669 @default.
- W2322152904 cites W2324797733 @default.
- W2322152904 cites W2333797862 @default.
- W2322152904 doi "https://doi.org/10.1186/s13014-016-0630-x" @default.
- W2322152904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4826496" @default.
- W2322152904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27061083" @default.
- W2322152904 hasPublicationYear "2016" @default.
- W2322152904 type Work @default.
- W2322152904 sameAs 2322152904 @default.
- W2322152904 citedByCount "36" @default.
- W2322152904 countsByYear W23221529042016 @default.
- W2322152904 countsByYear W23221529042017 @default.
- W2322152904 countsByYear W23221529042018 @default.
- W2322152904 countsByYear W23221529042019 @default.
- W2322152904 countsByYear W23221529042020 @default.
- W2322152904 countsByYear W23221529042021 @default.
- W2322152904 countsByYear W23221529042022 @default.
- W2322152904 countsByYear W23221529042023 @default.
- W2322152904 crossrefType "journal-article" @default.
- W2322152904 hasAuthorship W2322152904A5002341560 @default.
- W2322152904 hasAuthorship W2322152904A5030089962 @default.
- W2322152904 hasAuthorship W2322152904A5038693643 @default.
- W2322152904 hasAuthorship W2322152904A5038981517 @default.
- W2322152904 hasAuthorship W2322152904A5039064680 @default.
- W2322152904 hasAuthorship W2322152904A5048589047 @default.
- W2322152904 hasAuthorship W2322152904A5060433852 @default.
- W2322152904 hasAuthorship W2322152904A5063880741 @default.
- W2322152904 hasAuthorship W2322152904A5083170859 @default.
- W2322152904 hasAuthorship W2322152904A5086970088 @default.
- W2322152904 hasAuthorship W2322152904A5090700846 @default.
- W2322152904 hasBestOaLocation W23221529041 @default.
- W2322152904 hasConcept C126322002 @default.
- W2322152904 hasConcept C141071460 @default.
- W2322152904 hasConcept C2780037786 @default.
- W2322152904 hasConcept C3018411727 @default.
- W2322152904 hasConcept C509974204 @default.
- W2322152904 hasConcept C71924100 @default.
- W2322152904 hasConceptScore W2322152904C126322002 @default.
- W2322152904 hasConceptScore W2322152904C141071460 @default.
- W2322152904 hasConceptScore W2322152904C2780037786 @default.
- W2322152904 hasConceptScore W2322152904C3018411727 @default.
- W2322152904 hasConceptScore W2322152904C509974204 @default.
- W2322152904 hasConceptScore W2322152904C71924100 @default.
- W2322152904 hasIssue "1" @default.