FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322201465> ?p ?o ?g. }

• W2322201465 endingPage "5855" @default.
• W2322201465 startingPage "5844" @default.
• W2322201465 abstract "In this article, we report the photophysical and biological properties of new luminescent rhenium(I) polypyridine fluorous complexes. The complexes [Re(N∧N)(CO)3(py-Rf-NH2)](PF6) (py-Rf-NH2 = 3-amino-5-(N-((3-perfluorooctyl)propyl)aminocarbonyl)pyridine; N∧N = 1,10-phenanthroline (phen) (1a), 3,4,7,8-tetramethyl-1,10-phenanthroline (Me4-phen) (2a), 4,7-diphenyl-1,10-phenanthroline (Ph2-phen) (3a)) contain a fluorous pendant and a primary amine for modification. They have been converted to the isothiocyanate complexes [Re(N∧N)(CO)3(py-Rf-NCS)](PF6) (py-Rf-NCS = 3-isothiocyanato-5-(N-((3-perfluorooctyl)propyl)aminocarbonyl)pyridine; N∧N = phen (1b), Me4-phen (2b), Ph2-phen (3b)) with thiophosgene. The isothiocyanate complexes have been reacted with ethylamine, a model substrate, yielding the thiourea complexes [Re(N∧N)(CO)3(py-Rf-TU-Et)](PF6) (py-Rf-TU-Et = 3-ethylthioureidyl-5-(N-((3-perfluorooctyl)propyl)aminocarbonyl)pyridine; N∧N = phen (1c), Me4-phen (2c), Ph2-phen (3c)). Upon irradiation, all of these fluorous complexes exhibited intense and long-lived green-to-yellow triplet metal-to-ligand charge-transfer (3MLCT) (dπ(Re) → π*(N∧N)) emission in fluid solutions at 298 K and in rigid glass at 77 K. The lipophilicity, cellular uptake properties, and cytotoxicity of the amine and thiourea complexes have been studied. Results of MTT assays showed that the less lipophilic fluorous complexes displayed higher cytotoxicity. The isothiocyanate complexes 1b–3b have been used to label glutathione (GSH), bovine serum albumin (BSA), branched poly(ethyleneimine) (bPEI, average Mw = 25 kDa), and poly-l-lysine (Poly-K, Mw > 30 kDa); the photophysical properties of the resultant conjugates have been examined. Additionally, we have demonstrated that the GSH conjugates can be readily isolated and purified with fluorous solid phase extraction. The uptake of complex 3c and the conjugate BSA-3c by HeLa cells has also been studied by laser-scanning confocal microscopy. Furthermore, the DNA-binding and polyplex-formation properties of the conjugates bPEI-3c and Poly-K-3c have been investigated." @default.
• W2322201465 created "2016-06-24" @default.
• W2322201465 creator A5030511610 @default.
• W2322201465 creator A5031282547 @default.
• W2322201465 creator A5054430995 @default.
• W2322201465 creator A5081167307 @default.
• W2322201465 creator A5088364443 @default.
• W2322201465 date "2012-07-02" @default.
• W2322201465 modified "2023-09-24" @default.
• W2322201465 title "Synthesis, Emission Characteristics, Cellular Studies, and Bioconjugation Properties of Luminescent Rhenium(I) Polypyridine Complexes with a Fluorous Pendant" @default.
• W2322201465 cites W1580847663 @default.
• W2322201465 cites W1964603841 @default.
• W2322201465 cites W1969099049 @default.
• W2322201465 cites W1971768489 @default.
• W2322201465 cites W1971826830 @default.
• W2322201465 cites W1975175276 @default.
• W2322201465 cites W1976081059 @default.
• W2322201465 cites W1976259581 @default.
• W2322201465 cites W1976401479 @default.
• W2322201465 cites W1977902200 @default.
• W2322201465 cites W1978055923 @default.
• W2322201465 cites W1979150917 @default.
• W2322201465 cites W1979393989 @default.
• W2322201465 cites W1987477754 @default.
• W2322201465 cites W1991300442 @default.
• W2322201465 cites W1992191876 @default.
• W2322201465 cites W1994440550 @default.
• W2322201465 cites W1997107645 @default.
• W2322201465 cites W1998314279 @default.
• W2322201465 cites W1998945486 @default.
• W2322201465 cites W2003110973 @default.
• W2322201465 cites W2003494704 @default.
• W2322201465 cites W2003904826 @default.
• W2322201465 cites W2004312995 @default.
• W2322201465 cites W2004838689 @default.
• W2322201465 cites W2006915836 @default.
• W2322201465 cites W2009508594 @default.
• W2322201465 cites W2018008206 @default.
• W2322201465 cites W2022436069 @default.
• W2322201465 cites W2024917185 @default.
• W2322201465 cites W2025007445 @default.
• W2322201465 cites W2025229651 @default.
• W2322201465 cites W2025442425 @default.
• W2322201465 cites W2033267029 @default.
• W2322201465 cites W2035952646 @default.
• W2322201465 cites W2037567771 @default.
• W2322201465 cites W2039546223 @default.
• W2322201465 cites W2040899202 @default.
• W2322201465 cites W2043621010 @default.
• W2322201465 cites W2044228378 @default.
• W2322201465 cites W2045727661 @default.
• W2322201465 cites W2047487034 @default.
• W2322201465 cites W2047962120 @default.
• W2322201465 cites W2048336297 @default.
• W2322201465 cites W2050324076 @default.
• W2322201465 cites W2050975214 @default.
• W2322201465 cites W2051564409 @default.
• W2322201465 cites W2051652511 @default.
• W2322201465 cites W2052353798 @default.
• W2322201465 cites W2054527847 @default.
• W2322201465 cites W2058021921 @default.
• W2322201465 cites W2058365077 @default.
• W2322201465 cites W2059511412 @default.
• W2322201465 cites W2060686534 @default.
• W2322201465 cites W2063902820 @default.
• W2322201465 cites W2064198043 @default.
• W2322201465 cites W2073142205 @default.
• W2322201465 cites W2074440421 @default.
• W2322201465 cites W2074816329 @default.
• W2322201465 cites W2075148912 @default.
• W2322201465 cites W2076785262 @default.
• W2322201465 cites W2079309979 @default.
• W2322201465 cites W2080923904 @default.
• W2322201465 cites W2080988955 @default.
• W2322201465 cites W2083309296 @default.
• W2322201465 cites W2084778302 @default.
• W2322201465 cites W2086659710 @default.
• W2322201465 cites W2088583618 @default.
• W2322201465 cites W2092447252 @default.
• W2322201465 cites W2096318240 @default.
• W2322201465 cites W2101407709 @default.
• W2322201465 cites W2101738309 @default.
• W2322201465 cites W2106911911 @default.
• W2322201465 cites W2114918609 @default.
• W2322201465 cites W2121585421 @default.
• W2322201465 cites W2137440879 @default.
• W2322201465 cites W2142987628 @default.
• W2322201465 cites W2148659800 @default.
• W2322201465 cites W2162563641 @default.
• W2322201465 cites W2163667373 @default.
• W2322201465 cites W2327151284 @default.
• W2322201465 cites W2495287617 @default.
• W2322201465 cites W2951408969 @default.
• W2322201465 cites W4254457975 @default.
• W2322201465 doi "https://doi.org/10.1021/om3003575" @default.
• W2322201465 hasPublicationYear "2012" @default.
• W2322201465 type Work @default.
• W2322201465 sameAs 2322201465 @default.

• next