FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322226648> ?p ?o ?g. }

• W2322226648 endingPage "3686" @default.
• W2322226648 startingPage "3679" @default.
• W2322226648 abstract "Glycopolypeptides with a defined secondary structure are of significance in understanding biological phenomena. Synthetic glycopolypeptides, or polypeptides featuring pendant carbohydrate moieties, have been of particular interest in the field of tissue engineering and drug delivery. In this work, we have synthesized charged water-soluble glycopolypeptides that adopt a helical conformation in water. This was carried out by the synthesis of a glyco-N-carboxyanhydride (glyco-NCA) containing an azide group at the sixth position of the carbohydrate ring. Subsequently, the NCA was polymerized to obtain azide-containing glycopolypeptides having good control over molecular weight and polydispersity index (PDI) in high yields. We were also able to control the incorporation of the azide group by synthesizing random co-glycopolypeptide containing 6-deoxy-6-azido and regular 6-OAc functionalized glucose. This azide functionality allows for the easy attachment of a bioactive group, which could potentially enhance the biological activity of the glycopolypeptide. We were able to obtain water-soluble charged glycopolypeptides by both reducing the azide groups into amines and using CuAAC with propargylamine. These charged glycopolypeptides were shown to have a helical conformation in water. Preliminary studies showed that these charged glycopolypeptides showed good biocompatibility and were efficiently taken up by HepG2 cells." @default.
• W2322226648 created "2016-06-24" @default.
• W2322226648 creator A5002199469 @default.
• W2322226648 creator A5031301718 @default.
• W2322226648 creator A5031872284 @default.
• W2322226648 creator A5067265421 @default.
• W2322226648 creator A5067825939 @default.
• W2322226648 creator A5089650083 @default.
• W2322226648 date "2014-09-02" @default.
• W2322226648 modified "2023-10-14" @default.
• W2322226648 title "Cationic Charged Helical Glycopolypeptide Using Ring Opening Polymerization of 6-Deoxy-6-azido-glyco-<i>N</i>-carboxyanhydride" @default.
• W2322226648 cites W1552550319 @default.
• W2322226648 cites W1964815923 @default.
• W2322226648 cites W1967059698 @default.
• W2322226648 cites W1967178214 @default.
• W2322226648 cites W1969043476 @default.
• W2322226648 cites W1973895050 @default.
• W2322226648 cites W1985800275 @default.
• W2322226648 cites W1987205935 @default.
• W2322226648 cites W1989489362 @default.
• W2322226648 cites W1992777087 @default.
• W2322226648 cites W2001492234 @default.
• W2322226648 cites W2001710494 @default.
• W2322226648 cites W2019296527 @default.
• W2322226648 cites W2019372644 @default.
• W2322226648 cites W2022732803 @default.
• W2322226648 cites W2028986432 @default.
• W2322226648 cites W2030625213 @default.
• W2322226648 cites W2032521942 @default.
• W2322226648 cites W2035327865 @default.
• W2322226648 cites W2038834359 @default.
• W2322226648 cites W2040415005 @default.
• W2322226648 cites W2050377203 @default.
• W2322226648 cites W2057112987 @default.
• W2322226648 cites W2063057685 @default.
• W2322226648 cites W2063780640 @default.
• W2322226648 cites W2065699213 @default.
• W2322226648 cites W2078757968 @default.
• W2322226648 cites W2080304455 @default.
• W2322226648 cites W2080896529 @default.
• W2322226648 cites W2083560628 @default.
• W2322226648 cites W2086671454 @default.
• W2322226648 cites W2088497317 @default.
• W2322226648 cites W2090201623 @default.
• W2322226648 cites W2092097760 @default.
• W2322226648 cites W2103357027 @default.
• W2322226648 cites W2107237747 @default.
• W2322226648 cites W2114042611 @default.
• W2322226648 cites W2118615978 @default.
• W2322226648 cites W2119761013 @default.
• W2322226648 cites W2121011186 @default.
• W2322226648 cites W2123238521 @default.
• W2322226648 cites W2126818937 @default.
• W2322226648 cites W2129885169 @default.
• W2322226648 cites W2136227935 @default.
• W2322226648 cites W2138159091 @default.
• W2322226648 cites W2144602253 @default.
• W2322226648 cites W2145772823 @default.
• W2322226648 cites W2146032846 @default.
• W2322226648 cites W2154507957 @default.
• W2322226648 cites W2314186146 @default.
• W2322226648 cites W2322243638 @default.
• W2322226648 cites W2334745441 @default.
• W2322226648 doi "https://doi.org/10.1021/bm5009537" @default.
• W2322226648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25122513" @default.
• W2322226648 hasPublicationYear "2014" @default.
• W2322226648 type Work @default.
• W2322226648 sameAs 2322226648 @default.
• W2322226648 citedByCount "20" @default.
• W2322226648 countsByYear W23222266482015 @default.
• W2322226648 countsByYear W23222266482016 @default.
• W2322226648 countsByYear W23222266482017 @default.
• W2322226648 countsByYear W23222266482018 @default.
• W2322226648 countsByYear W23222266482019 @default.
• W2322226648 countsByYear W23222266482020 @default.
• W2322226648 countsByYear W23222266482021 @default.
• W2322226648 countsByYear W23222266482022 @default.
• W2322226648 crossrefType "journal-article" @default.
• W2322226648 hasAuthorship W2322226648A5002199469 @default.
• W2322226648 hasAuthorship W2322226648A5031301718 @default.
• W2322226648 hasAuthorship W2322226648A5031872284 @default.
• W2322226648 hasAuthorship W2322226648A5067265421 @default.
• W2322226648 hasAuthorship W2322226648A5067825939 @default.
• W2322226648 hasAuthorship W2322226648A5089650083 @default.
• W2322226648 hasConcept C11432220 @default.
• W2322226648 hasConcept C178790620 @default.
• W2322226648 hasConcept C183882617 @default.
• W2322226648 hasConcept C185592680 @default.
• W2322226648 hasConcept C188027245 @default.
• W2322226648 hasConcept C203897987 @default.
• W2322226648 hasConcept C21951064 @default.
• W2322226648 hasConcept C2777230088 @default.
• W2322226648 hasConcept C2780997848 @default.
• W2322226648 hasConcept C44228677 @default.
• W2322226648 hasConcept C521977710 @default.
• W2322226648 hasConceptScore W2322226648C11432220 @default.
• W2322226648 hasConceptScore W2322226648C178790620 @default.
• W2322226648 hasConceptScore W2322226648C183882617 @default.

• next