FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322230810> ?p ?o ?g. }

• W2322230810 endingPage "174480691663347" @default.
• W2322230810 startingPage "174480691663347" @default.
• W2322230810 abstract "BackgroundClinical management of neuropathic pain, which is pain arising as a consequence of a lesion or a disease affecting the somatosensory system, partly relies on the use of anticonvulsant drugs such as gabapentinoids. Therapeutic action of gabapentinoids such as gabapentin and pregabalin, which act by the inhibition of calcium currents through interaction with the α2δ-1 subunit of voltage-dependent calcium channels, is well documented. However, some aspects of the downstream mechanisms are still to be uncovered. Using behavioral, genetic, and pharmacological approaches, we tested whether opioid receptors are necessary for the antiallodynic action of acute and/or long-term pregabalin treatment in the specific context of neuropathic pain. ResultsUsing the cuff model of neuropathic pain in mice, we show that acute pregabalin administration at high dose has a transitory antiallodynic action, while prolonged oral pregabalin treatment leads to sustained antiallodynic action, consistent with clinical observations. We show that pregabalin remains fully effective in μ-opioid receptor, in δ-opioid receptor and in κ-opioid receptor deficient mice, either female or male, and its antiallodynic action is not affected by acute naloxone. Our work also shows that long-term pregabalin treatment suppresses tumor necrosis factor-α overproduction induced by sciatic nerve constriction in the lumbar dorsal root ganglia. ConclusionsWe demonstrate that neither acute nor long-term antiallodynic effect of pregabalin in a context of neuropathic pain is mediated by the endogenous opioid system, which differs from opioid treatment of pain and antidepressant treatment of neuropathic pain. Our data are also supportive of an impact of gabapentinoid treatment on the neuroimmune aspect of neuropathic pain." @default.
• W2322230810 created "2016-06-24" @default.
• W2322230810 creator A5001354414 @default.
• W2322230810 creator A5005993049 @default.
• W2322230810 creator A5009845605 @default.
• W2322230810 creator A5010130905 @default.
• W2322230810 creator A5025198948 @default.
• W2322230810 creator A5039811767 @default.
• W2322230810 creator A5077494333 @default.
• W2322230810 creator A5078402834 @default.
• W2322230810 creator A5090012638 @default.
• W2322230810 date "2016-01-01" @default.
• W2322230810 modified "2023-10-18" @default.
• W2322230810 title "The antiallodynic action of pregabalin in neuropathic pain is independent from the opioid system" @default.
• W2322230810 cites W1443596138 @default.
• W2322230810 cites W1505495051 @default.
• W2322230810 cites W1533446611 @default.
• W2322230810 cites W1601972531 @default.
• W2322230810 cites W1630835083 @default.
• W2322230810 cites W1738040396 @default.
• W2322230810 cites W1764861907 @default.
• W2322230810 cites W1976812888 @default.
• W2322230810 cites W1979100111 @default.
• W2322230810 cites W1981480712 @default.
• W2322230810 cites W1981942371 @default.
• W2322230810 cites W1988016240 @default.
• W2322230810 cites W1988209540 @default.
• W2322230810 cites W1988452935 @default.
• W2322230810 cites W1988855325 @default.
• W2322230810 cites W1992056759 @default.
• W2322230810 cites W1993532733 @default.
• W2322230810 cites W1994334998 @default.
• W2322230810 cites W1995976449 @default.
• W2322230810 cites W1996985329 @default.
• W2322230810 cites W1997476828 @default.
• W2322230810 cites W2005625267 @default.
• W2322230810 cites W2010972175 @default.
• W2322230810 cites W2011561633 @default.
• W2322230810 cites W2019993833 @default.
• W2322230810 cites W2021532501 @default.
• W2322230810 cites W2022344016 @default.
• W2322230810 cites W2027053525 @default.
• W2322230810 cites W2031737952 @default.
• W2322230810 cites W2042741271 @default.
• W2322230810 cites W2045436300 @default.
• W2322230810 cites W2051746492 @default.
• W2322230810 cites W2052342473 @default.
• W2322230810 cites W2052654632 @default.
• W2322230810 cites W2063158307 @default.
• W2322230810 cites W2064405147 @default.
• W2322230810 cites W2069323374 @default.
• W2322230810 cites W2070651571 @default.
• W2322230810 cites W2073844986 @default.
• W2322230810 cites W2074476845 @default.
• W2322230810 cites W2082358146 @default.
• W2322230810 cites W2082885661 @default.
• W2322230810 cites W2084190290 @default.
• W2322230810 cites W2092211307 @default.
• W2322230810 cites W2092472739 @default.
• W2322230810 cites W2103289578 @default.
• W2322230810 cites W2104818454 @default.
• W2322230810 cites W2111964682 @default.
• W2322230810 cites W2112469160 @default.
• W2322230810 cites W2115451671 @default.
• W2322230810 cites W2128202887 @default.
• W2322230810 cites W2129972576 @default.
• W2322230810 cites W2131113697 @default.
• W2322230810 cites W2138295551 @default.
• W2322230810 cites W2140682024 @default.
• W2322230810 cites W2143382058 @default.
• W2322230810 cites W2148741199 @default.
• W2322230810 cites W2152872860 @default.
• W2322230810 cites W2153448546 @default.
• W2322230810 cites W2162878610 @default.
• W2322230810 cites W2165005697 @default.
• W2322230810 cites W2171872873 @default.
• W2322230810 cites W2261044925 @default.
• W2322230810 cites W2318063355 @default.
• W2322230810 cites W2784619920 @default.
• W2322230810 doi "https://doi.org/10.1177/1744806916633477" @default.
• W2322230810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4956392" @default.
• W2322230810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27030724" @default.
• W2322230810 hasPublicationYear "2016" @default.
• W2322230810 type Work @default.
• W2322230810 sameAs 2322230810 @default.
• W2322230810 citedByCount "26" @default.
• W2322230810 countsByYear W23222308102016 @default.
• W2322230810 countsByYear W23222308102017 @default.
• W2322230810 countsByYear W23222308102018 @default.
• W2322230810 countsByYear W23222308102019 @default.
• W2322230810 countsByYear W23222308102020 @default.
• W2322230810 countsByYear W23222308102021 @default.
• W2322230810 countsByYear W23222308102022 @default.
• W2322230810 countsByYear W23222308102023 @default.
• W2322230810 crossrefType "journal-article" @default.
• W2322230810 hasAuthorship W2322230810A5001354414 @default.
• W2322230810 hasAuthorship W2322230810A5005993049 @default.
• W2322230810 hasAuthorship W2322230810A5009845605 @default.

• next