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• W2322255499 abstract "The adaptive mechanisms underlying the well described effect of low-intensity resistance exercise (RE) with blood flow restriction (BFR) to increase muscle strength and muscle mass in humans are not fully understood. Although the influence of Akt/mTOR signalling and a stimulating effect on protein synthesis have been demonstrated, the potential role of myogenic satellite cell activation has not been examined. In the present study BFR RE was hypothesized to activate myogenic satellite cells (SC) expressing Pax-7. PURPOSE: To examine the effect of short-term low-intensity RE with BFR on the activation of Pax7+ SC in relation to muscle cell growth and myonuclei distribution. METHODS: 10 young men (23 ±2 yrs) completed 7 sessions of BFR knee extensor resistance exercise (20% 1-RM load) in 5 days. Training consisted of 4 sets of isolated knee extensor contractions (20% 1-RM loads) to concentric failure during concurrent blood flow restriction (100 mmHg cuff pressure). Muscle biopsies were obtained (VL) at baseline (pre) and day 8 (post 2 days resting). SC expressing Pax-7, myonuclei density and muscle fiber area were assessed by immunohistochemistry. RESULTS: Type I and II fiber area increased with BFR training from 4051.1 ± 592.9 to 5575.6 ± 1614.8 μm2 and from 4227.5 ± 756.1 to 6240.4 ± 1875.5 μm2 (p<0.05). SC and myonuclei data did not differ between type I and II muscle fibers and therefore were pooled. Pax7+ SC number per muscle fiber increased 4-fold (0.101 ± 0.027 to 0.383 ± 0.065) (p<0.01). Likewise, Pax7+ SC per myonuclei increased 3-fold (0.040 ± 0.010 to 0.119 ± 0.027) (p<0.01). Myonuclei number per muscle fiber increased 35% (2.51 ± 0.22 to 3.30 ± 0.65) (p<0.05). Nuclear domain did not change with training (1917 ± 248 vs. 2053 ± 514 μm2/nuclei). Mean muscle fiber CSA was related to Pax-7 positive SC per muscle fiber pre and post training (r=0.6-0.7) (p<0.05). CONCLUSION: Five days (7 sessions) of low-resistance training using BFR led to marked muscle fiber hypertrophy (+37 to +48%) that was accompanied by highly upregulated satellite cell activation and myonuclei addition. Further, Pax7+ satellite cell number was positively related to myofiber size pre and post training. Thus the accelerated hypertrophy response with BFR at least in part seems to rely on an amplified myogenic satellite cell activation and myonuclei addition." @default.
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• W2322255499 date "2011-05-01" @default.
• W2322255499 modified "2023-10-10" @default.
• W2322255499 title "Rapid Increases in Myogenic Satellite Cells Expressing Pax-7 with Blood Flow Restricted Low-intensity Resistance Training" @default.
• W2322255499 doi "https://doi.org/10.1249/01.mss.0000402091.97477.4b" @default.
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