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- W2322263274 abstract "We investigated the inhibition of mushroom tyrosinase in Smilax china. A methanol (MeOH) extract of S. china was partitioned into hexane, ethyl acetate (EtOAc) and water. Of the 3 fractions, EtOAc extract showed the strongest inhibition of tyrosinase activity with L-tyrosine or L-DOPA as a substrate. Two compounds were isolated from a final active fraction by activity-guided column chromatography. These compounds were identified as dioscin and oxyresveratrol. We discovered that a mixture of oxyresveratrol and dioscin (IC50=5.1, 5.7µg/ml) highly increased the inhibition of tyrosinase activity with L-tyrosine or L-DOPA as the substrate as compared to either oxyresveratrol (IC50=7.8, 10.9µg/ml) or dioscin (IC50 >100, 100µg/ml) alone." @default.
- W2322263274 created "2016-06-24" @default.
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- W2322263274 date "2012-07-01" @default.
- W2322263274 modified "2023-10-16" @default.
- W2322263274 title "Synergistic tyronsinase inhibitors from the roots of Smilax china" @default.
- W2322263274 doi "https://doi.org/10.1055/s-0032-1321011" @default.
- W2322263274 hasPublicationYear "2012" @default.
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