FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322300598> ?p ?o ?g. }

• W2322300598 endingPage "373" @default.
• W2322300598 startingPage "367" @default.
• W2322300598 abstract "Pancreatic cancer is a devastating disease, with a median survival of around 6 months for patients with stage IV disease. The epidermal growth factor receptor (EGFR, or HER1) belongs to the erbB receptor tyrosine kinase family. HER1-mediated cell signaling has been shown to play a major role in promoting tumor proliferation, angiogenesis, metastasis, and evasion of apoptosis. Over-expression of HER1 is observed in multiple human malignancies, including colorectal, lung, breast and pancreatic cancers. In pancreatic carcinoma, over-expression of HER1 is observed in greater than 70% of patients and is associated with a poor prognosis and a significant decrease in survival. Cetuximab (Erbitux) is a chimeric monoclonal antibody (mAb) that binds to the extracellular domain of the HER1 molecule preventing ligand binding and promoting internalization and subsequent degradation of the HER1 receptor. Cetuximab has shown anti-tumor activity either alone or in combination with other agents and is currently FDA approved for use in both squamous cell carcinoma of the head and neck (SCCHN) and colorectal carcinoma. Research efforts continue to elucidate a possible role for cetuximab in the treatment of pancreatic cancer. Despite promising preclinical work, phase II and phase III clinical trials have failed to consistently show efficacy of cetuximab treatment in advanced pancreatic cancer either alone or in combination with cytotoxic agents. Alternative approaches to HER1 blockade and mAbs including immune modulation with cytokines might be necessary in order to improve the efficacy of mAbs in pancreatic cancer therapy." @default.
• W2322300598 created "2016-06-24" @default.
• W2322300598 creator A5001832483 @default.
• W2322300598 creator A5023228070 @default.
• W2322300598 creator A5060897770 @default.
• W2322300598 creator A5080897550 @default.
• W2322300598 date "2012-06-01" @default.
• W2322300598 modified "2023-10-18" @default.
• W2322300598 title "Monoclonal Antibody Therapy of Pancreatic Cancer With Cetuximab" @default.
• W2322300598 cites W118213103 @default.
• W2322300598 cites W1480344559 @default.
• W2322300598 cites W1499740654 @default.
• W2322300598 cites W1532588163 @default.
• W2322300598 cites W1606226434 @default.
• W2322300598 cites W1856489512 @default.
• W2322300598 cites W1924088703 @default.
• W2322300598 cites W1931508686 @default.
• W2322300598 cites W1939364580 @default.
• W2322300598 cites W1958728059 @default.
• W2322300598 cites W1964508470 @default.
• W2322300598 cites W1967210005 @default.
• W2322300598 cites W1974024530 @default.
• W2322300598 cites W1979789707 @default.
• W2322300598 cites W1990783767 @default.
• W2322300598 cites W2004942295 @default.
• W2322300598 cites W2006073656 @default.
• W2322300598 cites W2008803651 @default.
• W2322300598 cites W2009043731 @default.
• W2322300598 cites W2020920166 @default.
• W2322300598 cites W2023660230 @default.
• W2322300598 cites W2025313715 @default.
• W2322300598 cites W2031118586 @default.
• W2322300598 cites W2032474425 @default.
• W2322300598 cites W2038832181 @default.
• W2322300598 cites W2038882649 @default.
• W2322300598 cites W2043642585 @default.
• W2322300598 cites W2044360617 @default.
• W2322300598 cites W2054870962 @default.
• W2322300598 cites W2058678021 @default.
• W2322300598 cites W2060974366 @default.
• W2322300598 cites W2078776989 @default.
• W2322300598 cites W2088539087 @default.
• W2322300598 cites W2097328301 @default.
• W2322300598 cites W2102897408 @default.
• W2322300598 cites W2104810237 @default.
• W2322300598 cites W2112964045 @default.
• W2322300598 cites W2112966339 @default.
• W2322300598 cites W2114666853 @default.
• W2322300598 cites W2122080125 @default.
• W2322300598 cites W2123206362 @default.
• W2322300598 cites W2125662786 @default.
• W2322300598 cites W2126240154 @default.
• W2322300598 cites W2127214162 @default.
• W2322300598 cites W2128402413 @default.
• W2322300598 cites W2132268212 @default.
• W2322300598 cites W2136871952 @default.
• W2322300598 cites W2138426249 @default.
• W2322300598 cites W2141312960 @default.
• W2322300598 cites W2142442804 @default.
• W2322300598 cites W2142564546 @default.
• W2322300598 cites W2142845582 @default.
• W2322300598 cites W2144025124 @default.
• W2322300598 cites W2145854263 @default.
• W2322300598 cites W2154740756 @default.
• W2322300598 cites W2155305458 @default.
• W2322300598 cites W2155384808 @default.
• W2322300598 cites W2157824687 @default.
• W2322300598 cites W2159506251 @default.
• W2322300598 cites W2161482321 @default.
• W2322300598 cites W2168377135 @default.
• W2322300598 cites W2171369860 @default.
• W2322300598 cites W2208092455 @default.
• W2322300598 cites W2314331148 @default.
• W2322300598 cites W2115790682 @default.
• W2322300598 doi "https://doi.org/10.1097/cji.0b013e3182562d76" @default.
• W2322300598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3353011" @default.
• W2322300598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22576341" @default.
• W2322300598 hasPublicationYear "2012" @default.
• W2322300598 type Work @default.
• W2322300598 sameAs 2322300598 @default.
• W2322300598 citedByCount "25" @default.
• W2322300598 countsByYear W23223005982012 @default.
• W2322300598 countsByYear W23223005982013 @default.
• W2322300598 countsByYear W23223005982014 @default.
• W2322300598 countsByYear W23223005982015 @default.
• W2322300598 countsByYear W23223005982016 @default.
• W2322300598 countsByYear W23223005982017 @default.
• W2322300598 countsByYear W23223005982018 @default.
• W2322300598 countsByYear W23223005982019 @default.
• W2322300598 countsByYear W23223005982020 @default.
• W2322300598 countsByYear W23223005982021 @default.
• W2322300598 crossrefType "journal-article" @default.
• W2322300598 hasAuthorship W2322300598A5001832483 @default.
• W2322300598 hasAuthorship W2322300598A5023228070 @default.
• W2322300598 hasAuthorship W2322300598A5060897770 @default.
• W2322300598 hasAuthorship W2322300598A5080897550 @default.
• W2322300598 hasBestOaLocation W23223005982 @default.
• W2322300598 hasConcept C121608353 @default.

• next