Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322327213> ?p ?o ?g. }
- W2322327213 abstract "Cathelicidins form a family of vertebrate-specific immune molecules with an evolutionarily conserved gene structure. We analyzed the expression patterns of cathelicidin genes (CAMP, CATH3, and CATHB1) in chicken bone marrow cells (BMCs) and chicken embryonic fibroblasts (CEFs). We found that CAMP and CATHB1 were significantly up-regulated in BMCs, whereas the expression of CATH3 did not differ significantly between BMCs and CEFs. To study the mechanism underlying the up-regulation of cathelicidin genes in BMCs, we predicted the transcription factors (TFs) that bind to the 5'-flanking regions of cathelicidin genes. CEBPA, EBF1, HES1, MSX1, and ZIC3 were up-regulated in BMCs compared to CEFs. Subsequently, when a siRNA-mediated knockdown assay was performed for MSX1, the expression of CAMP and CATHB1 was decreased in BMCs. We also showed that the transcriptional activity of the CAMP promoter was decreased by mutation of the MSX1-binding sites present within the 5'-flanking region of CAMP. These results increase our understanding of the regulatory mechanisms controlling cathelicidin genes in BMCs." @default.
- W2322327213 created "2016-06-24" @default.
- W2322327213 creator A5014477545 @default.
- W2322327213 creator A5020022157 @default.
- W2322327213 creator A5023093492 @default.
- W2322327213 creator A5028092000 @default.
- W2322327213 creator A5042881145 @default.
- W2322327213 creator A5062648459 @default.
- W2322327213 creator A5078436317 @default.
- W2322327213 date "2016-04-01" @default.
- W2322327213 modified "2023-10-14" @default.
- W2322327213 title "Transcriptional regulation of cathelicidin genes in chicken bone marrow cells" @default.
- W2322327213 cites W1505446510 @default.
- W2322327213 cites W1513303790 @default.
- W2322327213 cites W1514256649 @default.
- W2322327213 cites W1577531106 @default.
- W2322327213 cites W1676840812 @default.
- W2322327213 cites W186885137 @default.
- W2322327213 cites W1896164923 @default.
- W2322327213 cites W1921818371 @default.
- W2322327213 cites W1949010695 @default.
- W2322327213 cites W1964758221 @default.
- W2322327213 cites W1969783259 @default.
- W2322327213 cites W1972181361 @default.
- W2322327213 cites W1973615192 @default.
- W2322327213 cites W1978359304 @default.
- W2322327213 cites W1981854518 @default.
- W2322327213 cites W1982064271 @default.
- W2322327213 cites W2000049370 @default.
- W2322327213 cites W2000219282 @default.
- W2322327213 cites W2005343978 @default.
- W2322327213 cites W2022283846 @default.
- W2322327213 cites W2034280103 @default.
- W2322327213 cites W2038121569 @default.
- W2322327213 cites W2044373024 @default.
- W2322327213 cites W2064993419 @default.
- W2322327213 cites W2068020539 @default.
- W2322327213 cites W2069384013 @default.
- W2322327213 cites W2078519856 @default.
- W2322327213 cites W2081077386 @default.
- W2322327213 cites W2083798813 @default.
- W2322327213 cites W2084973068 @default.
- W2322327213 cites W2091371315 @default.
- W2322327213 cites W2093697574 @default.
- W2322327213 cites W2094036101 @default.
- W2322327213 cites W2096108228 @default.
- W2322327213 cites W2099126603 @default.
- W2322327213 cites W2100589217 @default.
- W2322327213 cites W2109570941 @default.
- W2322327213 cites W2113368990 @default.
- W2322327213 cites W2117618216 @default.
- W2322327213 cites W2125644936 @default.
- W2322327213 cites W2126516803 @default.
- W2322327213 cites W2137119310 @default.
- W2322327213 cites W2145484765 @default.
- W2322327213 cites W2149401354 @default.
- W2322327213 cites W2164128280 @default.
- W2322327213 cites W2166047130 @default.
- W2322327213 cites W2168575718 @default.
- W2322327213 doi "https://doi.org/10.3382/ps/pev361" @default.
- W2322327213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26908883" @default.
- W2322327213 hasPublicationYear "2016" @default.
- W2322327213 type Work @default.
- W2322327213 sameAs 2322327213 @default.
- W2322327213 citedByCount "5" @default.
- W2322327213 countsByYear W23223272132018 @default.
- W2322327213 countsByYear W23223272132019 @default.
- W2322327213 countsByYear W23223272132020 @default.
- W2322327213 countsByYear W23223272132021 @default.
- W2322327213 countsByYear W23223272132023 @default.
- W2322327213 crossrefType "journal-article" @default.
- W2322327213 hasAuthorship W2322327213A5014477545 @default.
- W2322327213 hasAuthorship W2322327213A5020022157 @default.
- W2322327213 hasAuthorship W2322327213A5023093492 @default.
- W2322327213 hasAuthorship W2322327213A5028092000 @default.
- W2322327213 hasAuthorship W2322327213A5042881145 @default.
- W2322327213 hasAuthorship W2322327213A5062648459 @default.
- W2322327213 hasAuthorship W2322327213A5078436317 @default.
- W2322327213 hasBestOaLocation W23223272131 @default.
- W2322327213 hasConcept C104317684 @default.
- W2322327213 hasConcept C136449434 @default.
- W2322327213 hasConcept C145103041 @default.
- W2322327213 hasConcept C153911025 @default.
- W2322327213 hasConcept C173396325 @default.
- W2322327213 hasConcept C27153228 @default.
- W2322327213 hasConcept C2777379352 @default.
- W2322327213 hasConcept C2780538058 @default.
- W2322327213 hasConcept C45091340 @default.
- W2322327213 hasConcept C54355233 @default.
- W2322327213 hasConcept C86339819 @default.
- W2322327213 hasConcept C86803240 @default.
- W2322327213 hasConcept C8891405 @default.
- W2322327213 hasConcept C95444343 @default.
- W2322327213 hasConceptScore W2322327213C104317684 @default.
- W2322327213 hasConceptScore W2322327213C136449434 @default.
- W2322327213 hasConceptScore W2322327213C145103041 @default.
- W2322327213 hasConceptScore W2322327213C153911025 @default.
- W2322327213 hasConceptScore W2322327213C173396325 @default.
- W2322327213 hasConceptScore W2322327213C27153228 @default.
- W2322327213 hasConceptScore W2322327213C2777379352 @default.