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• W2322345108 abstract "Due to the short half-life of reactive oxygen species (ROS) such as a superoxide radical, controlled and localized generation of ROS is challenging. Here, we report a rationally designed small-molecule 1c that generates ROS only when triggered by a bacterial enzyme. We provide evidence for 1c predictably enhancing the intracellular superoxide radical in a model bacterium. Spatiotemporal control over ROS generation offered by 1c should help better understand stress responses in bacteria to increased ROS." @default.
• W2322345108 created "2016-06-24" @default.
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• W2322345108 date "2013-12-27" @default.
• W2322345108 modified "2023-10-16" @default.
• W2322345108 title "A Small Molecule for Controlled Generation of Reactive Oxygen Species (ROS)" @default.
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• W2322345108 doi "https://doi.org/10.1021/ol403300a" @default.
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