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• W2322359989 endingPage "79" @default.
• W2322359989 startingPage "71" @default.
• W2322359989 abstract "<b><i>Background:</i></b> Platelets are implicated in many pathophysiological processes, including inflammation and immunity. Ever-growing evidence suggests the active involvement of platelets in the pathogenesis of various inflammatory disorders, including cutaneous inflammatory diseases. A limited number of studies have investigated the role of platelets in chronic urticaria (CU). In this review, we summarize the current knowledge regarding the role of platelets in chronic spontaneous and inducible urticarias. <b><i>Methods:</i></b> A literature search was performed using PubMed and Google Scholar, and the references of relevant literature were reviewed. <b><i>Results:</i></b> Overall, in CU patients, conflicting results have been obtained from the assessment of platelet indices, such as mean platelet volume, platelet count and distribution width, as well as markers of platelet aggregation and activation. Nevertheless, a few studies showed significant changes of such parameters in CU patients compared to controls, in apparent correlation with clinical severity, autoreactivity and/or inflammatory status. <b><i>Conclusions:</i></b> In the absence of definitive conclusions, the pathogenic role of platelets in CU needs to be further explored. Platelets might represent a link between inflammation, coagulation and histamine release in the pathophysiological network of CU." @default.
• W2322359989 created "2016-06-24" @default.
• W2322359989 creator A5005532978 @default.
• W2322359989 creator A5015789010 @default.
• W2322359989 creator A5077042932 @default.
• W2322359989 creator A5084575229 @default.
• W2322359989 date "2016-01-01" @default.
• W2322359989 modified "2023-09-27" @default.
• W2322359989 title "The Role of Platelets in Chronic Urticaria" @default.
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• W2322359989 doi "https://doi.org/10.1159/000444085" @default.
• W2322359989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27035367" @default.

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