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• W2322366886 abstract "Purpose: Muscle weakness is a universal finding in knee osteoarthritis (OA) patients, leading to limitations in daily activities such as walking and rising from a chair. Among other determinants of muscle weakness in knee OA patients, non-contractile tissue including fatty tissue, connective tissue and inflammatory tissue, could contribute to lower muscle strength in this population. Studies determining the association between non-contractile tissue and muscle strength have shown conflicting results. Therefore, the study aims were to establish the association of non-contractile tissue in the vastus medialis, assessed by magnetic resonance imaging (MRI) to muscle strength in patients with established knee OA. Methods: In a cross-sectional study, participants of the AMS-OA cohort (n = 94) were included. Sagittal T1 weighted MR images, conducted at 3 Tesla, were performed using a phased array knee coil. The thickness of the vastus medialis muscle was measured. The relationship between contractile tissue and non-contractile tissue was expressed as the percentage of non-contractile tissue in a standardized region of interest. Muscle strength in extension was assessed isokinetically (Nm). The Get-Up and Go time, as a functional test of muscle strength, was used as a measurement of physical function. Based on the median, percentage of non-contractile tissue was dichotomized into low and high percentage non-contractile tissue groups. In statistical analysis, differences in demographics and clinical characteristics between the groups a low percentage of non-contractile tissue versus a high percentage of non-contractile tissue were calculated using a Student’s t-test. In regression analyses the associations of a low versus a high percentage of non-contractile tissue to muscle strength and Get-Up and Go test were determined. In multivariable regression analysis these associations were controlled for age, radiographic severity (Kellgren & Lawrence grade) and vastus medialis thickness. Results: Participant characteristics are shown in Table 1. The mean ± SD percentage of non-contractile tissue was 16.03 ± 15.31 with a median of 11%. The participants with a high percentage of non-contractile tissue (> 11%) had on average less muscle strength, a longer Get-Up and Go time and a higher BMI than participants with a lower percentage of non-contractile tissue (≤ 11%) (P = 0.031, P = 0.021, P = 0.026, respectively). Multivariable regression analysis, adjusting for age, radiographic severity (Kellgren & Lawrence grade) and vastus medialis thickness, showed that the percentage of non-contractile tissue was negatively associated with muscle strength and Get-Up and Go time (P = 0.037, P = 0.024, respectively), indicating that a high percentage of non-contractile tissue was associated with lower muscle strength and a longer Get-Up and Go time. Conclusions: Non-contractile tissue of the vastus medialis on MRI is a contributing factor to muscle weakness in patients with established knee OA. The percentage contractile and non-contractile tissue may have utility as a marker of the severity of muscle weakness in patients with knee OA.Tabled 1Participant characteristics (Mean ± Standard deviation, unless otherwise stated)Total groupLow percentage of non-contractile tissue (≤ 11%)High percentage of non-contractile tissue (> 11%)P-valueMean ± SDMean ± SDMean ± SDN944747Gender (n,% female)65 (69.1)30 (63.8)35 (74.5)0.264Age, years61.68 ± 7.0961.64 ± 6.7761.72 ± 7.470.954BMI, kg/m229.13 ± 4.7228.05 ± 3.9930.21 ± 5.170.026Radiographic severity, K/L grade30 (31.9)17 (36.2)13 (27.7)0.376Radiographic severity, K/L grade ≥2 (n, %)64 (68.1)30 (63.8)34 (72.3)Vastus medialis thickness, mm46.56 ± 7.5347.13 ± 7.9146.00 ± 7.160.469Muscle strength, Nm74.62 ± 43.0884.13 ± 48.5265.10 ± 34.830.031Get-Up and Go time, seconds10.86 ± 2.3110.32 ± 2.2111.41 ± 2.290.021 Open table in a new tab" @default.
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• W2322366886 date "2016-04-01" @default.
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• W2322366886 title "The association between non-contractile tissue in the vastus medialis muscle assessed by MRI and muscle strength in patients with established knee OA; results from the AMS-OA cohort" @default.
• W2322366886 doi "https://doi.org/10.1016/j.joca.2016.01.746" @default.
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