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- W2322380010 abstract "Iskemik modifiye albumin (IMA) koroner arter hastaligi tanisinda son yillarda kullanilmaya baslanilan yeni bir belirtectir. Doksanli yillarin sonunda akut koroner sendromlu hastalarin serumunda bulunan insan serum albumininin, ekzojen kobalti (Co) baglamasinda azalma oldugu tespit edilmis ve ardindan iskemi modifiye albumin olarak bilinen bu metabolik varyant, “Albumin Kobalt Baglanma” testi ile olculebilir hale getirilmistir. IMA bu konuda FDA onayi da almistir. IMA, iskemide serumda 10 dakika icinde tespit edilmektedir. Bu sure miyoglobulin, CK-MB, troponinC’nin kanda ortaya ciktigi sureye bakildiginda oldukca kisadir (Sekil 1). IMA’nin akut koroner hadiselerde troponin ve EKG ile birlikte %95’lik bir tanisal degeri oldugu bazi calismalarda saptanmistir. Gunumuzde IMA’in miyokard iskemisi, iskelet kas iskemisi, mezenterik iskemi, inme ve serebrovaskuler kazalar gibi bircok durumda belirtec olarak onemi gosterilmektedir. IMA tayini, albumine kobaltin azalan baglanma kapasitesi, Bar ve ark. tarafindan gelistirilen hizli ve kolorimetrik tayin yontemi ile degerlendirilir. Sonuclar absorbans unitesi (ABSU) cinsinden rapor edilir. Onerdildigi gibi 0.400 ABSU uzerindeki degerlerin dusuk kobalt baglanmasini, dolayisiyla da iskemiyi gosterdigi kabul edilirken; 0.400 ABSU altindaki degerler ise iskemi olmadigi seklinde degerlendirilir." @default.
- W2322380010 created "2016-06-24" @default.
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- W2322380010 date "2012-01-01" @default.
- W2322380010 modified "2023-09-25" @default.
- W2322380010 title "The use of ischemia modified albumin in emergency surgery" @default.
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- W2322380010 doi "https://doi.org/10.5505/jkartaltr.2012.94809" @default.
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