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- W2322406871 abstract "The migration and invasion inhibitory protein (MIIP) gene encodes an inhibitor of cancer cell migration and invasion. Our previous studies using the colony formation assay have demonstrated that MIIP also inhibits tumorigenesis in breast cancer cells. Therefore, we hypothesized that genetic variations in MIIP may affect breast cancer development and prognosis. In this case-control study, we genotyped the MIIP single nucleotide polymorphism (SNP) rs2295283 (codon 167, A>G, K>E) from 1524 breast cancer patients and 1592 age-matched controls for its association with breast cancer risk. The SNP analysis was next performed on a validation set (736 cases and 760 controls). Colony formation and cell migration assays were then conducted to functionally interrogate the difference between the A and G variants. Compared with the AA genotype in both the test and validation sets, the combined AG+GG genotypes (167E) were associated with a significantly lower risk of breast cancer. Among the test set, the protective effect of the AG+GG genotypes was more evident among participants with a family history of cancer. Further case series analysis revealed that the GG genotype was less susceptible to breast cancer with tumor size >2 cm and late clinical stage (II+III+IV). Colony formation assays showed that MIIP 167E (the G variant) was a more potent inhibitor of colony formation but not cell migration. These results suggest that MIIP K167E SNP may be a genetic predictor of breast cancer development and prognosis, as supported by differential abilities of the two isoforms in inhibiting breast cancer colony formation in vitro. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2840." @default.
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- W2322406871 date "2010-04-15" @default.
- W2322406871 modified "2023-09-27" @default.
- W2322406871 title "Abstract 2840: A functional nonsynonymous single nucleotide polymorphism in the migration and invasion inhibitory protein (MIIP)gene confers differential risk of breast cancer" @default.
- W2322406871 doi "https://doi.org/10.1158/1538-7445.am10-2840" @default.
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