FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322448708> ?p ?o ?g. }

• W2322448708 endingPage "324" @default.
• W2322448708 startingPage "318" @default.
• W2322448708 abstract "Objective: Rasagiline, a monoamine oxidase type B inhibitor, is indicated for both the initial treatment of Parkinson disease (PD) and as adjunctive (add-on) treatment for patients already taking dopaminergic therapy. This open-label prospective community-based clinical trial was designed to determine the time-to-onset and the magnitude of the beneficial effects of rasagiline in PD patients. Methods: Patients received rasagiline of 1.0 mg once daily as monotherapy or 0.5 mg once daily as adjunct therapy (adjunct therapy dose could be increased to 1 mg/d if clinically indicated) for 12 weeks. Dietary restrictions and recommendations regarding concurrent antidepressant treatment consistent with the Food and Drug Administration (FDA) regulations were in keeping with typical usage. Effectiveness was measured as change from baseline in bradykinesia scores and physicians’ and patients’ global impression. Patients were prospectively monitored for treatment emergent dopaminergic side effects, tyramine reactions, and possible interactions with commonly used antidepressants. Results: Objective and subjective measures of symptom severity improved at 1 week in 272 PD patients treated with once-daily rasagiline (n=123 monotherapy, n=149 adjunct therapy). The magnitude of beneficial effect was similar in monotherapy and adjunct therapy patients. No significant dopaminergic side effects, tyramine reactions, or interactions with antidepressants were observed in the 12-week trial. Conclusions: Rasagiline has a measurable beneficial effect on PD symptoms within 1 week of treatment. Rasagiline has a similar magnitude of benefit in monotherapy and adjunct therapy patients. Adverse interactions between antidepressants and rasagiline were not observed in patients in this trial. The usual use of rasagiline in community neurology practice, consistent with the FDA labeling, seems safe and effective." @default.
• W2322448708 created "2016-06-24" @default.
• W2322448708 creator A5001199868 @default.
• W2322448708 creator A5005434953 @default.
• W2322448708 creator A5006007407 @default.
• W2322448708 creator A5017329873 @default.
• W2322448708 creator A5053287624 @default.
• W2322448708 creator A5074852122 @default.
• W2322448708 date "2011-11-01" @default.
• W2322448708 modified "2023-09-27" @default.
• W2322448708 title "Rasagiline" @default.
• W2322448708 cites W1919842320 @default.
• W2322448708 cites W1974352826 @default.
• W2322448708 cites W1978042435 @default.
• W2322448708 cites W1978766093 @default.
• W2322448708 cites W2005270822 @default.
• W2322448708 cites W2009845708 @default.
• W2322448708 cites W2013110094 @default.
• W2322448708 cites W2024770800 @default.
• W2322448708 cites W2044368552 @default.
• W2322448708 cites W2055641052 @default.
• W2322448708 cites W2067346519 @default.
• W2322448708 cites W2093531337 @default.
• W2322448708 cites W2136406052 @default.
• W2322448708 cites W2151320291 @default.
• W2322448708 cites W2152111408 @default.
• W2322448708 cites W2152727843 @default.
• W2322448708 cites W37005 @default.
• W2322448708 cites W49996880 @default.
• W2322448708 doi "https://doi.org/10.1097/nrl.0b013e31822f6872" @default.
• W2322448708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22045282" @default.
• W2322448708 hasPublicationYear "2011" @default.
• W2322448708 type Work @default.
• W2322448708 sameAs 2322448708 @default.
• W2322448708 citedByCount "11" @default.
• W2322448708 countsByYear W23224487082013 @default.
• W2322448708 countsByYear W23224487082014 @default.
• W2322448708 countsByYear W23224487082015 @default.
• W2322448708 crossrefType "journal-article" @default.
• W2322448708 hasAuthorship W2322448708A5001199868 @default.
• W2322448708 hasAuthorship W2322448708A5005434953 @default.
• W2322448708 hasAuthorship W2322448708A5006007407 @default.
• W2322448708 hasAuthorship W2322448708A5017329873 @default.
• W2322448708 hasAuthorship W2322448708A5053287624 @default.
• W2322448708 hasAuthorship W2322448708A5074852122 @default.
• W2322448708 hasConcept C126322002 @default.
• W2322448708 hasConcept C137183658 @default.
• W2322448708 hasConcept C138885662 @default.
• W2322448708 hasConcept C181199279 @default.
• W2322448708 hasConcept C185592680 @default.
• W2322448708 hasConcept C197934379 @default.
• W2322448708 hasConcept C2776024655 @default.
• W2322448708 hasConcept C2776134090 @default.
• W2322448708 hasConcept C2777056012 @default.
• W2322448708 hasConcept C2778630814 @default.
• W2322448708 hasConcept C2779134260 @default.
• W2322448708 hasConcept C2779734285 @default.
• W2322448708 hasConcept C2781249495 @default.
• W2322448708 hasConcept C41895202 @default.
• W2322448708 hasConcept C42219234 @default.
• W2322448708 hasConcept C500440147 @default.
• W2322448708 hasConcept C513476851 @default.
• W2322448708 hasConcept C535046627 @default.
• W2322448708 hasConcept C55493867 @default.
• W2322448708 hasConcept C71924100 @default.
• W2322448708 hasConcept C98274493 @default.
• W2322448708 hasConceptScore W2322448708C126322002 @default.
• W2322448708 hasConceptScore W2322448708C137183658 @default.
• W2322448708 hasConceptScore W2322448708C138885662 @default.
• W2322448708 hasConceptScore W2322448708C181199279 @default.
• W2322448708 hasConceptScore W2322448708C185592680 @default.
• W2322448708 hasConceptScore W2322448708C197934379 @default.
• W2322448708 hasConceptScore W2322448708C2776024655 @default.
• W2322448708 hasConceptScore W2322448708C2776134090 @default.
• W2322448708 hasConceptScore W2322448708C2777056012 @default.
• W2322448708 hasConceptScore W2322448708C2778630814 @default.
• W2322448708 hasConceptScore W2322448708C2779134260 @default.
• W2322448708 hasConceptScore W2322448708C2779734285 @default.
• W2322448708 hasConceptScore W2322448708C2781249495 @default.
• W2322448708 hasConceptScore W2322448708C41895202 @default.
• W2322448708 hasConceptScore W2322448708C42219234 @default.
• W2322448708 hasConceptScore W2322448708C500440147 @default.
• W2322448708 hasConceptScore W2322448708C513476851 @default.
• W2322448708 hasConceptScore W2322448708C535046627 @default.
• W2322448708 hasConceptScore W2322448708C55493867 @default.
• W2322448708 hasConceptScore W2322448708C71924100 @default.
• W2322448708 hasConceptScore W2322448708C98274493 @default.
• W2322448708 hasIssue "6" @default.
• W2322448708 hasLocation W23224487081 @default.
• W2322448708 hasLocation W23224487082 @default.
• W2322448708 hasOpenAccess W2322448708 @default.
• W2322448708 hasPrimaryLocation W23224487081 @default.
• W2322448708 hasRelatedWork W1225351505 @default.
• W2322448708 hasRelatedWork W1974352826 @default.
• W2322448708 hasRelatedWork W2015987533 @default.
• W2322448708 hasRelatedWork W2026893785 @default.
• W2322448708 hasRelatedWork W2035347482 @default.
• W2322448708 hasRelatedWork W2111629536 @default.

• next