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- W2322453670 abstract "Intact atrial septum combined with either critical aortic stenosis (CAS) or hypoplastic left heart syndrome (HLHS) is associated with high mortality rates. Premature closure of the oval fossa is associated with left atrial hypertension that leads to pulmonary venous remodelling and lymphangiectasia. To date, histomorphologic investigations evaluating the influence of increased left atrial pressures on lung development, and alveolar maturation are lacking. In a retrospective case control study, we investigated lung tissue obtained from 18 autopsies of foetuses, neonates and infants with CAS and HLHS with intact atrial septum, 18 control tissues of normal lungs, and 8 lung tissues of patients with CAS and HLHS with unrestrictive inter-atrial communications. Pulmonary maturation was evaluated according to pulmonary vascular and capillary changes, development of alveoli, interstitial changes, and epithelial coating of alveolar surfaces by means of morphometric and immunohistochemical analysis. Differences were observed with respect to capillarisation of alveolar septae between groups as early as in week 23 of pregnancy. Interstitial haemorrhage and oedema increased till birth. Intactness of the atrial septum most strongly affected aveolar septal diameter. Significant differences could be shown from late second trimester on. Histopathologic findings reveal that foetal lung maturation with respect to alveolo-capillary vascularisation and alveolar membrane formation is severely deteriorated in patients with CAS and HLHS and intact atrial septum. Earliest alterations can be detected in 23 weeks of gestational age." @default.
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- W2322453670 date "2014-09-19" @default.
- W2322453670 modified "2023-10-18" @default.
- W2322453670 title "Third-trimester pulmonary maturation is significantly disturbed in patients with intact inter-atrial septum combined with mitral atresia, hypoplastic left heart syndrome or critical aortic stenosis" @default.
- W2322453670 doi "https://doi.org/10.1055/s-0034-1394018" @default.
- W2322453670 hasPublicationYear "2014" @default.
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