Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322464142> ?p ?o ?g. }
- W2322464142 endingPage "22833" @default.
- W2322464142 startingPage "22819" @default.
- W2322464142 abstract "Retinal pigment epithelium (RPE) transplantation is a particularly promising treatment of retinal degenerative diseases affecting RPE-photoreceptor complex. Embryonic stem cells (ESCs) provide an abundant donor source for RPE transplantation. Herein, we studied the time-course characteristics of RPE cells derived from three-dimensional human ESCs cultures (3D-RPE). We showed that 3D-RPE cells possessed morphology, ultrastructure, gene expression profile, and functions of authentic RPE. As differentiation proceeded, 3D-RPE cells could mature gradually with decreasing proliferation but increasing functions. Besides, 3D-RPE cells could form polarized monolayer with functional tight junction and gap junction. When grafted into the subretinal space of Royal College of Surgeons rats, 3D-RPE cells were safe and efficient to rescue retinal degeneration. This study showed that 3D-RPE cells were a new donor for cell therapy of retinal degenerative diseases." @default.
- W2322464142 created "2016-06-24" @default.
- W2322464142 creator A5025329094 @default.
- W2322464142 creator A5036596554 @default.
- W2322464142 creator A5048851743 @default.
- W2322464142 creator A5052442260 @default.
- W2322464142 creator A5056217891 @default.
- W2322464142 creator A5069660312 @default.
- W2322464142 date "2016-03-18" @default.
- W2322464142 modified "2023-10-04" @default.
- W2322464142 title "Features specific to retinal pigment epithelium cells derived from three-dimensional human embryonic stem cell cultures — a new donor for cell therapy" @default.
- W2322464142 cites W114316392 @default.
- W2322464142 cites W1483496013 @default.
- W2322464142 cites W1593266928 @default.
- W2322464142 cites W1968515560 @default.
- W2322464142 cites W1969005651 @default.
- W2322464142 cites W1970977410 @default.
- W2322464142 cites W1973207504 @default.
- W2322464142 cites W1981279491 @default.
- W2322464142 cites W1987713800 @default.
- W2322464142 cites W1989089629 @default.
- W2322464142 cites W1991894095 @default.
- W2322464142 cites W1992915966 @default.
- W2322464142 cites W2001503236 @default.
- W2322464142 cites W2008927161 @default.
- W2322464142 cites W2016602601 @default.
- W2322464142 cites W2021724765 @default.
- W2322464142 cites W2035318710 @default.
- W2322464142 cites W2036505824 @default.
- W2322464142 cites W2037210976 @default.
- W2322464142 cites W2040807722 @default.
- W2322464142 cites W2045048112 @default.
- W2322464142 cites W2048127413 @default.
- W2322464142 cites W2048140742 @default.
- W2322464142 cites W2064963302 @default.
- W2322464142 cites W2073947789 @default.
- W2322464142 cites W2074314696 @default.
- W2322464142 cites W2075701227 @default.
- W2322464142 cites W2086314362 @default.
- W2322464142 cites W2091315047 @default.
- W2322464142 cites W2092167465 @default.
- W2322464142 cites W2103693357 @default.
- W2322464142 cites W2111274886 @default.
- W2322464142 cites W2127688669 @default.
- W2322464142 cites W2130576009 @default.
- W2322464142 cites W2140348983 @default.
- W2322464142 cites W2149884610 @default.
- W2322464142 cites W2153149309 @default.
- W2322464142 cites W2227187219 @default.
- W2322464142 cites W2322363882 @default.
- W2322464142 cites W804972530 @default.
- W2322464142 doi "https://doi.org/10.18632/oncotarget.8185" @default.
- W2322464142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5008403" @default.
- W2322464142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27009841" @default.
- W2322464142 hasPublicationYear "2016" @default.
- W2322464142 type Work @default.
- W2322464142 sameAs 2322464142 @default.
- W2322464142 citedByCount "23" @default.
- W2322464142 countsByYear W23224641422017 @default.
- W2322464142 countsByYear W23224641422018 @default.
- W2322464142 countsByYear W23224641422019 @default.
- W2322464142 countsByYear W23224641422020 @default.
- W2322464142 countsByYear W23224641422021 @default.
- W2322464142 countsByYear W23224641422022 @default.
- W2322464142 countsByYear W23224641422023 @default.
- W2322464142 crossrefType "journal-article" @default.
- W2322464142 hasAuthorship W2322464142A5025329094 @default.
- W2322464142 hasAuthorship W2322464142A5036596554 @default.
- W2322464142 hasAuthorship W2322464142A5048851743 @default.
- W2322464142 hasAuthorship W2322464142A5052442260 @default.
- W2322464142 hasAuthorship W2322464142A5056217891 @default.
- W2322464142 hasAuthorship W2322464142A5069660312 @default.
- W2322464142 hasBestOaLocation W23224641421 @default.
- W2322464142 hasConcept C104317684 @default.
- W2322464142 hasConcept C105702510 @default.
- W2322464142 hasConcept C10882517 @default.
- W2322464142 hasConcept C118487528 @default.
- W2322464142 hasConcept C141071460 @default.
- W2322464142 hasConcept C142724271 @default.
- W2322464142 hasConcept C145103041 @default.
- W2322464142 hasConcept C169760540 @default.
- W2322464142 hasConcept C2777093970 @default.
- W2322464142 hasConcept C2778024200 @default.
- W2322464142 hasConcept C2780827179 @default.
- W2322464142 hasConcept C2781040256 @default.
- W2322464142 hasConcept C28328180 @default.
- W2322464142 hasConcept C2911091166 @default.
- W2322464142 hasConcept C54355233 @default.
- W2322464142 hasConcept C71924100 @default.
- W2322464142 hasConcept C86803240 @default.
- W2322464142 hasConcept C95444343 @default.
- W2322464142 hasConceptScore W2322464142C104317684 @default.
- W2322464142 hasConceptScore W2322464142C105702510 @default.
- W2322464142 hasConceptScore W2322464142C10882517 @default.
- W2322464142 hasConceptScore W2322464142C118487528 @default.
- W2322464142 hasConceptScore W2322464142C141071460 @default.
- W2322464142 hasConceptScore W2322464142C142724271 @default.
- W2322464142 hasConceptScore W2322464142C145103041 @default.