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- W2322482652 abstract "In this prospective, double-blind, monocenter drug trial, 48 primary care patients with mild to moderate essential hypertension were randomized to mibefradil, 50 mg, titrated to 100 mg, or enalapril, 20 mg, titrated to 2 × 20 mg. Ambulatory 24-h blood pressure measurements (ABPM) and echocardiography were performed at baseline and after 12 weeks' treatment. Complete data from 43 patients were analyzed. Mibefradil (n = 22; titration, 13 patients) reduced mean 24-h ABP from 159 ± 14/102 ± 7 mm Hg to 140 ± 10/89 ± 7 mm Hg after 12 weeks. Enalapril (n = 21; titration, six patients) reduced baseline ABP from 156 ± 12/100 ± 9 mm Hg to 140 ± 17/89 ± 10 mm Hg (12 weeks). Trough-to-peak ratios in DBP were 86% for mibefradil and 75% with enalapril. Left ventricular mass (LVM) decreased from 199 ± 65 to 193 ± 62 g [M-mode modified American Society of Echocardiography (ASE)] and from 184 ± 65 to 173 ± 50 g (truncated ellipsoid method) after 12 weeks in response to mibefradil (p > 0.2), and from 212 ± 50 to 196 ± 57 g and from 182 ± 39 to 170 ± 40 g (mean ± SD, p < 0.02) with enalapril. Mibefradil matched enalapril in 24-h ABP control. Enalapril reduced LVM significantly after 12 weeks (p < 0.02). Mibefradil did not significantly reduce LVM after 12 weeks." @default.
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- W2322482652 date "1999-04-01" @default.
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- W2322482652 title "The Effects of Mibefradil and Enalapril on 24-Hour Blood Pressure Control and Left Ventricular Mass in Patients with Mild to Moderate Hypertension: Double-Blind, Randomized Trial" @default.
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- W2322482652 doi "https://doi.org/10.1097/00005344-199904000-00019" @default.
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