Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322609596> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2322609596 endingPage "178" @default.
- W2322609596 startingPage "166" @default.
- W2322609596 abstract "Novel cancer cellular therapy approaches involving long-term ex vivo IL-2 stimulated highly cytotoxic natural killer (NK) cells are emerging. However, adhesion properties of such NK cells are not very well understood. Herein, we describe the novel observation of permanently activated alphaLbeta2 integrin leukocyte function-associated antigen (LFA)-1 adhesion receptor in long-term IL-2 activated NK cells and the permanent NK cell lines KHYG-1 and NK-92. We show that such cytokine activated NK effectors constitutively adhered to the LFA-1-ligand ICAM-1, whereas binding to the lower affinity ligand ICAM-3 required additional exogenous activating conditions. The results demonstrate an extended conformation and an intermediate affinity state for the LFA-1 population expressed by the NK cells. Interestingly, adhesion to ICAM-1 or K562 induced pronounced cell spreading in KHYG-1, but not in NK-92, and partially in long-term IL-2 stimulated primary NK cells. It is conceivable that such differential adhesion characteristics may impact motility potential of such NK effectors with relevance to clinical tumor targeting. KHYG-1 could be a useful model in planning future targeted therapeutic approaches involving NK effectors with augmented functions." @default.
- W2322609596 created "2016-06-24" @default.
- W2322609596 creator A5017623113 @default.
- W2322609596 creator A5031435676 @default.
- W2322609596 creator A5036742508 @default.
- W2322609596 creator A5039363824 @default.
- W2322609596 creator A5058334675 @default.
- W2322609596 creator A5078744845 @default.
- W2322609596 creator A5080353142 @default.
- W2322609596 date "2011-01-01" @default.
- W2322609596 modified "2023-10-14" @default.
- W2322609596 title "KHYG-1 and NK-92 represent different subtypes of LFA-1-mediated NK cell adhesiveness" @default.
- W2322609596 doi "https://doi.org/10.2741/e230" @default.
- W2322609596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21196295" @default.
- W2322609596 hasPublicationYear "2011" @default.
- W2322609596 type Work @default.
- W2322609596 sameAs 2322609596 @default.
- W2322609596 citedByCount "5" @default.
- W2322609596 countsByYear W23226095962015 @default.
- W2322609596 countsByYear W23226095962016 @default.
- W2322609596 countsByYear W23226095962021 @default.
- W2322609596 countsByYear W23226095962023 @default.
- W2322609596 crossrefType "journal-article" @default.
- W2322609596 hasAuthorship W2322609596A5017623113 @default.
- W2322609596 hasAuthorship W2322609596A5031435676 @default.
- W2322609596 hasAuthorship W2322609596A5036742508 @default.
- W2322609596 hasAuthorship W2322609596A5039363824 @default.
- W2322609596 hasAuthorship W2322609596A5058334675 @default.
- W2322609596 hasAuthorship W2322609596A5078744845 @default.
- W2322609596 hasAuthorship W2322609596A5080353142 @default.
- W2322609596 hasBestOaLocation W23226095961 @default.
- W2322609596 hasConcept C122871604 @default.
- W2322609596 hasConcept C129374314 @default.
- W2322609596 hasConcept C1491633281 @default.
- W2322609596 hasConcept C149532602 @default.
- W2322609596 hasConcept C154317977 @default.
- W2322609596 hasConcept C171122931 @default.
- W2322609596 hasConcept C185592680 @default.
- W2322609596 hasConcept C202751555 @default.
- W2322609596 hasConcept C28651165 @default.
- W2322609596 hasConcept C502942594 @default.
- W2322609596 hasConcept C51785407 @default.
- W2322609596 hasConcept C55493867 @default.
- W2322609596 hasConcept C85789140 @default.
- W2322609596 hasConcept C86803240 @default.
- W2322609596 hasConcept C95444343 @default.
- W2322609596 hasConceptScore W2322609596C122871604 @default.
- W2322609596 hasConceptScore W2322609596C129374314 @default.
- W2322609596 hasConceptScore W2322609596C1491633281 @default.
- W2322609596 hasConceptScore W2322609596C149532602 @default.
- W2322609596 hasConceptScore W2322609596C154317977 @default.
- W2322609596 hasConceptScore W2322609596C171122931 @default.
- W2322609596 hasConceptScore W2322609596C185592680 @default.
- W2322609596 hasConceptScore W2322609596C202751555 @default.
- W2322609596 hasConceptScore W2322609596C28651165 @default.
- W2322609596 hasConceptScore W2322609596C502942594 @default.
- W2322609596 hasConceptScore W2322609596C51785407 @default.
- W2322609596 hasConceptScore W2322609596C55493867 @default.
- W2322609596 hasConceptScore W2322609596C85789140 @default.
- W2322609596 hasConceptScore W2322609596C86803240 @default.
- W2322609596 hasConceptScore W2322609596C95444343 @default.
- W2322609596 hasIssue "1" @default.
- W2322609596 hasLocation W23226095961 @default.
- W2322609596 hasLocation W23226095962 @default.
- W2322609596 hasOpenAccess W2322609596 @default.
- W2322609596 hasPrimaryLocation W23226095961 @default.
- W2322609596 hasRelatedWork W1861983754 @default.
- W2322609596 hasRelatedWork W2049687639 @default.
- W2322609596 hasRelatedWork W2072502005 @default.
- W2322609596 hasRelatedWork W2090648490 @default.
- W2322609596 hasRelatedWork W2093122832 @default.
- W2322609596 hasRelatedWork W2104899797 @default.
- W2322609596 hasRelatedWork W2166826644 @default.
- W2322609596 hasRelatedWork W2192821761 @default.
- W2322609596 hasRelatedWork W2803531504 @default.
- W2322609596 hasRelatedWork W587341786 @default.
- W2322609596 hasVolume "E3" @default.
- W2322609596 isParatext "false" @default.
- W2322609596 isRetracted "false" @default.
- W2322609596 magId "2322609596" @default.
- W2322609596 workType "article" @default.