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- W2322613034 abstract "These studies were performed especially from the viewpoints of chest physician.I. Clinical study: The rhinoscopic examination was done by otolaryngologists in 58 patients with respiratory diseases diagnosed by various methods including selective alveolo-bronchography. Sixty-seven percent of these patients had nasal and/or paranasal diseases. Among them, in the patients with bronchial asthma, 58% had sinusitis and 67% had allergic rhinitis, but in the patients with chronic bronchitis and chronic pulmonary emphysema, sinusitis ocurred more frequently than rhinitis.II. Experimental study: A. Respiratory defense mechanism and choanal flow. 1) Three hundred μl of tantalum-suspended human sputum and paranasal fluid were injected via a catheter into an anesthetized canine trachea and ciliary transport rate were roentogenographically measured. In normal dogs, the transport rate of paranasal fluid was 9.7±3.0mm/min as compared to 13.3±2.6mm/min in sputum.These values were extremely higher than those of other mucus or solutions. In a previous experiment, it was determined that the effect of gravity on ciliary transport was negligible when cilia were covered with appropriate mucus. So, it was proved that choanal fluid can be easily expelled out when it flows down into the normal lower respiratory tract. 2) The experimental study on infection promoting effect revealed that this effect of paranasal fluid was less than that of sputum from the lower respiratory tract.B. Cyclic nucleotides in the respiratory tracts of guinea pigs. Cyclic AMP and cyclic GMP in the respiratory tracts were measured by radioimmunoassay method. The levels of cyclic AMP and cyclic GMP were highest in lungs, and decreased in bronchi, trachea and nose in order. The lower value of cyclic AMP in nasal mucosa compared to the lower respiratory tract was supposed to be one of the factors predisposing the nasal mucosa to hypersensitivity.These results suggest that more attention should be paid to common genetic factors causing various disorders in both the upper and lower respiratory tracts." @default.
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- W2322613034 date "1978-01-01" @default.
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- W2322613034 title "Comparative Studies on Deference Mechanism of the Upper and Lower Respiratory Tracts" @default.
- W2322613034 doi "https://doi.org/10.2468/jbes.29.116" @default.
- W2322613034 hasPublicationYear "1978" @default.
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