FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322744561> ?p ?o ?g. }

• W2322744561 endingPage "1505" @default.
• W2322744561 startingPage "1492" @default.
• W2322744561 abstract "Spinal cord injury (SCI) can lead to permanent motor and sensory deficits. Following the initial traumatic insult, secondary injury mechanisms characterized by persistent heightened inflammation are initiated and lead to continued and pervasive cell death and tissue damage. Anti-inflammatory drugs such as methylprednisolone (MP) used clinically have ambiguous benefits with debilitating side effects. Typically, these drugs are administered systemically at high doses, resulting in toxicity and paradoxically increased inflammation. Furthermore, these drugs have a small time window postinjury (few hours) during which they need to be infused to be effective. As an alternative to MP, we investigated the effect of a small molecule inhibitor (Chicago sky blue, CSB) of macrophage migration inhibitory factor (MIF) for treating SCI. The pleiotropic cytokine MIF is known to contribute to upregulation of several pro-inflammatory cytokines in various disease and injury states. In vitro, CSB administration alleviated endotoxin-mediated inflammation in primary microglia and macrophages. Nanocarriers such as liposomes can potentially alleviate systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord. However, the therapeutic window of 100 nm scale nanoparticle localization to the spinal cord after contusion injury is not fully known. Thus, we first investigated the ability of nanocarriers of different sizes to localize to the injured spinal cord up to 2 weeks postinjury. Results from the study showed that nanocarriers as large as 200 nm in diameter could extravasate into the injured spinal cord up to 96 h postinjury. We then formulated nanocarriers (liposomes) encapsulating CSB and administered them intravenously 48 h postinjury, within the previously determined 96 h therapeutic window. In vivo, in this clinically relevant contusion injury model in rats, CSB administration led to preservation of vascular and white matter integrity, improved wound healing, and an increase in levels of arginase and other transcripts indicative of a resolution phase of wound healing. This study demonstrates the potential of MIF inhibition in SCI and the utility of nanocarrier-mediated drug delivery selectively to the injured cord." @default.
• W2322744561 created "2016-06-24" @default.
• W2322744561 creator A5001376491 @default.
• W2322744561 creator A5001500650 @default.
• W2322744561 creator A5002821515 @default.
• W2322744561 creator A5025632281 @default.
• W2322744561 creator A5046943484 @default.
• W2322744561 creator A5047219003 @default.
• W2322744561 creator A5072097405 @default.
• W2322744561 creator A5072608448 @default.
• W2322744561 date "2015-01-28" @default.
• W2322744561 modified "2023-10-12" @default.
• W2322744561 title "Nanocarrier-Mediated Inhibition of Macrophage Migration Inhibitory Factor Attenuates Secondary Injury after Spinal Cord Injury" @default.
• W2322744561 cites W1569061064 @default.
• W2322744561 cites W1797422316 @default.
• W2322744561 cites W1855045052 @default.
• W2322744561 cites W1908112684 @default.
• W2322744561 cites W1961906585 @default.
• W2322744561 cites W1965026439 @default.
• W2322744561 cites W1967109943 @default.
• W2322744561 cites W1969125125 @default.
• W2322744561 cites W1970024238 @default.
• W2322744561 cites W1977213877 @default.
• W2322744561 cites W1982079559 @default.
• W2322744561 cites W1982080317 @default.
• W2322744561 cites W1982300103 @default.
• W2322744561 cites W1984548348 @default.
• W2322744561 cites W1985222446 @default.
• W2322744561 cites W1989832114 @default.
• W2322744561 cites W1990200376 @default.
• W2322744561 cites W1997986888 @default.
• W2322744561 cites W1998752508 @default.
• W2322744561 cites W2005416260 @default.
• W2322744561 cites W2006517495 @default.
• W2322744561 cites W2007318225 @default.
• W2322744561 cites W2008082211 @default.
• W2322744561 cites W2009201448 @default.
• W2322744561 cites W2015202374 @default.
• W2322744561 cites W2016326033 @default.
• W2322744561 cites W2023053568 @default.
• W2322744561 cites W2029026381 @default.
• W2322744561 cites W202929248 @default.
• W2322744561 cites W2030112647 @default.
• W2322744561 cites W2030958472 @default.
• W2322744561 cites W2032760352 @default.
• W2322744561 cites W2039604691 @default.
• W2322744561 cites W2043015179 @default.
• W2322744561 cites W204511859 @default.
• W2322744561 cites W2049679215 @default.
• W2322744561 cites W2050571672 @default.
• W2322744561 cites W2052473808 @default.
• W2322744561 cites W2054440842 @default.
• W2322744561 cites W2055992710 @default.
• W2322744561 cites W2056241473 @default.
• W2322744561 cites W2060928497 @default.
• W2322744561 cites W2061399709 @default.
• W2322744561 cites W2062487182 @default.
• W2322744561 cites W2065700461 @default.
• W2322744561 cites W2065769697 @default.
• W2322744561 cites W2067583186 @default.
• W2322744561 cites W2068572014 @default.
• W2322744561 cites W2075288153 @default.
• W2322744561 cites W2079538438 @default.
• W2322744561 cites W2081022473 @default.
• W2322744561 cites W2081467080 @default.
• W2322744561 cites W2082511916 @default.
• W2322744561 cites W2092034907 @default.
• W2322744561 cites W2093097193 @default.
• W2322744561 cites W2093230923 @default.
• W2322744561 cites W2093738970 @default.
• W2322744561 cites W2097737287 @default.
• W2322744561 cites W2104968232 @default.
• W2322744561 cites W2107277218 @default.
• W2322744561 cites W2107446553 @default.
• W2322744561 cites W2117634037 @default.
• W2322744561 cites W2118878458 @default.
• W2322744561 cites W2121438383 @default.
• W2322744561 cites W2122400789 @default.
• W2322744561 cites W2126044151 @default.
• W2322744561 cites W2130388082 @default.
• W2322744561 cites W2130529018 @default.
• W2322744561 cites W2131581428 @default.
• W2322744561 cites W2132451011 @default.
• W2322744561 cites W2135553830 @default.
• W2322744561 cites W2140380746 @default.
• W2322744561 cites W2145435038 @default.
• W2322744561 cites W2146058212 @default.
• W2322744561 cites W2148418495 @default.
• W2322744561 cites W2149090625 @default.
• W2322744561 cites W2151417786 @default.
• W2322744561 cites W2160353065 @default.
• W2322744561 cites W2161456562 @default.
• W2322744561 cites W2162989569 @default.
• W2322744561 cites W2164475686 @default.
• W2322744561 cites W2166771618 @default.
• W2322744561 cites W2168448028 @default.
• W2322744561 cites W2171792381 @default.
• W2322744561 cites W2319923802 @default.

• next