Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322753652> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2322753652 endingPage "283" @default.
- W2322753652 startingPage "275" @default.
- W2322753652 abstract "Whether theranostic testing to discern person-to-person and population differences in drug metabolism pathways offers clinical guidance in oncology for fluoropyrimidines such as 5-fluorouracil (5-FU) remains an open question. Extensive basic and clinical studies have been performed over the past several decades with regard to personalizing treatment with fluoropyrimidines, optimizing patients quality of life and reducing risks for severe and fatal toxic events. A variety of genetic variants in the dihydropyrimidine dehydrogenase (DPYD) gene were thus identified, and have been clustered according to their clinical and predictive value. However, further research is still needed as the DPYD gene is highly variable, complicating the attempts to establish genotype-phenotype correlations. Therefore, to individualise 5-FU therapy, several integrative/complementary approaches appear to be indicated to determine the dihydropyrimidine dehydrogenase metabolizer status. In principle, these diagnostic approaches in assessing dihydropyrimidine dehydrogenase activity include genotyping and phenotyping for the DPYD. This paper presents a critical summary and evaluation of the current state of research on both DPYD genotyping and phenotyping, and the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase deficiency more generally. For DPYD based personalized medicine diagnostics to advance forward to become standard state of the art in routine testing, we also suggest the need for additional genetic, biological and clinical characterization of this pharmacologically significant variation across different global populations." @default.
- W2322753652 created "2016-06-24" @default.
- W2322753652 creator A5016840986 @default.
- W2322753652 creator A5045328967 @default.
- W2322753652 creator A5063021649 @default.
- W2322753652 creator A5067116615 @default.
- W2322753652 creator A5071022778 @default.
- W2322753652 creator A5080741846 @default.
- W2322753652 date "2009-12-01" @default.
- W2322753652 modified "2023-10-18" @default.
- W2322753652 title "Dihydropyrimidine Dehydrogenase Genotyping and Phenotyping for 5- Fluorouracil Dysmetabolism: Moving Towards Personalized Chemotherapy in Patients with Cancer" @default.
- W2322753652 doi "https://doi.org/10.2174/187569209790112328" @default.
- W2322753652 hasPublicationYear "2009" @default.
- W2322753652 type Work @default.
- W2322753652 sameAs 2322753652 @default.
- W2322753652 citedByCount "1" @default.
- W2322753652 crossrefType "journal-article" @default.
- W2322753652 hasAuthorship W2322753652A5016840986 @default.
- W2322753652 hasAuthorship W2322753652A5045328967 @default.
- W2322753652 hasAuthorship W2322753652A5063021649 @default.
- W2322753652 hasAuthorship W2322753652A5067116615 @default.
- W2322753652 hasAuthorship W2322753652A5071022778 @default.
- W2322753652 hasAuthorship W2322753652A5080741846 @default.
- W2322753652 hasConcept C104317684 @default.
- W2322753652 hasConcept C121608353 @default.
- W2322753652 hasConcept C123321153 @default.
- W2322753652 hasConcept C126322002 @default.
- W2322753652 hasConcept C135763542 @default.
- W2322753652 hasConcept C143998085 @default.
- W2322753652 hasConcept C2776694085 @default.
- W2322753652 hasConcept C2778050828 @default.
- W2322753652 hasConcept C2780456651 @default.
- W2322753652 hasConcept C31467283 @default.
- W2322753652 hasConcept C502942594 @default.
- W2322753652 hasConcept C54355233 @default.
- W2322753652 hasConcept C71924100 @default.
- W2322753652 hasConcept C86803240 @default.
- W2322753652 hasConceptScore W2322753652C104317684 @default.
- W2322753652 hasConceptScore W2322753652C121608353 @default.
- W2322753652 hasConceptScore W2322753652C123321153 @default.
- W2322753652 hasConceptScore W2322753652C126322002 @default.
- W2322753652 hasConceptScore W2322753652C135763542 @default.
- W2322753652 hasConceptScore W2322753652C143998085 @default.
- W2322753652 hasConceptScore W2322753652C2776694085 @default.
- W2322753652 hasConceptScore W2322753652C2778050828 @default.
- W2322753652 hasConceptScore W2322753652C2780456651 @default.
- W2322753652 hasConceptScore W2322753652C31467283 @default.
- W2322753652 hasConceptScore W2322753652C502942594 @default.
- W2322753652 hasConceptScore W2322753652C54355233 @default.
- W2322753652 hasConceptScore W2322753652C71924100 @default.
- W2322753652 hasConceptScore W2322753652C86803240 @default.
- W2322753652 hasIssue "4" @default.
- W2322753652 hasLocation W23227536521 @default.
- W2322753652 hasOpenAccess W2322753652 @default.
- W2322753652 hasPrimaryLocation W23227536521 @default.
- W2322753652 hasRelatedWork W1989798994 @default.
- W2322753652 hasRelatedWork W2001549857 @default.
- W2322753652 hasRelatedWork W2022230660 @default.
- W2322753652 hasRelatedWork W2182963545 @default.
- W2322753652 hasRelatedWork W2189014522 @default.
- W2322753652 hasRelatedWork W2322753652 @default.
- W2322753652 hasRelatedWork W2389866737 @default.
- W2322753652 hasRelatedWork W2407296146 @default.
- W2322753652 hasRelatedWork W3086478581 @default.
- W2322753652 hasRelatedWork W3125862781 @default.
- W2322753652 hasVolume "7" @default.
- W2322753652 isParatext "false" @default.
- W2322753652 isRetracted "false" @default.
- W2322753652 magId "2322753652" @default.
- W2322753652 workType "article" @default.