Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322753818> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2322753818 endingPage "326" @default.
- W2322753818 startingPage "323" @default.
- W2322753818 abstract "The incidence of cutaneous squamous cell carcinoma (SCC) is increasing worldwide. Despite a growing body of literature on prognostic factors, it remains unclear how tumor differentiation grade influences patient survival. The aim of this study was to investigate a possible correlation between cutaneous SCC differentiation, local recurrence, metastasis, and patient survival.All consecutive patients treated for cutaneous SCC between 2001 and 2008 were retrospectively analyzed. Univariate survival analysis was used to assess the association of different tumor characteristics with survival.One hundred thirty-one patients with 155 SCCs were included (median follow-up, 81 months; range, 27-125 months). Although no significant correlation between tumor differentiation grade and local recurrence could be found, it was an independent prognostic factor for metastatic disease and overall survival (OS). Metastasis-free survival at 5 years was significantly higher in well-differentiated tumors (70%) compared to moderately (51%) and poorly differentiated SCCs (26%; P = 0.012); identical percentages were found for OS (P = 0.005). Furthermore, patients with incomplete excision of the first tumor showed an increased relative risk of dying of SCC of 4.0 (95% confidence interval, 2.4-6.6; P < 0.001) compared to excision with clear margins.Studies that investigated the relationship between SCC differentiation grade and patient survival are scarce and inconsistent. The present study indicates tumor differentiation grade is an independent prognostic factor for OS. This finding suggests poor differentiation of cutaneous SCC alone is sufficient to upstage the primary tumor in the TNM classification system." @default.
- W2322753818 created "2016-06-24" @default.
- W2322753818 creator A5018120485 @default.
- W2322753818 creator A5034087287 @default.
- W2322753818 creator A5040082277 @default.
- W2322753818 creator A5078648606 @default.
- W2322753818 creator A5083170125 @default.
- W2322753818 creator A5083487213 @default.
- W2322753818 date "2015-09-01" @default.
- W2322753818 modified "2023-09-30" @default.
- W2322753818 title "The Effect of Differentiation Grade of Cutaneous Squamous Cell Carcinoma on Excision Margins, Local Recurrence, Metastasis, and Patient Survival" @default.
- W2322753818 cites W1529230314 @default.
- W2322753818 cites W1594237846 @default.
- W2322753818 cites W1994136786 @default.
- W2322753818 cites W1999538118 @default.
- W2322753818 cites W2009779656 @default.
- W2322753818 cites W2018404789 @default.
- W2322753818 cites W2028122932 @default.
- W2322753818 cites W2046292072 @default.
- W2322753818 cites W2053410866 @default.
- W2322753818 cites W2083146850 @default.
- W2322753818 cites W2086238536 @default.
- W2322753818 cites W2088720843 @default.
- W2322753818 cites W2088975143 @default.
- W2322753818 cites W2089167013 @default.
- W2322753818 cites W2093169814 @default.
- W2322753818 cites W2119358637 @default.
- W2322753818 cites W2171362247 @default.
- W2322753818 cites W2171921092 @default.
- W2322753818 doi "https://doi.org/10.1097/sap.0000000000000110" @default.
- W2322753818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24401812" @default.
- W2322753818 hasPublicationYear "2015" @default.
- W2322753818 type Work @default.
- W2322753818 sameAs 2322753818 @default.
- W2322753818 citedByCount "45" @default.
- W2322753818 countsByYear W23227538182015 @default.
- W2322753818 countsByYear W23227538182016 @default.
- W2322753818 countsByYear W23227538182017 @default.
- W2322753818 countsByYear W23227538182018 @default.
- W2322753818 countsByYear W23227538182019 @default.
- W2322753818 countsByYear W23227538182020 @default.
- W2322753818 countsByYear W23227538182021 @default.
- W2322753818 countsByYear W23227538182022 @default.
- W2322753818 countsByYear W23227538182023 @default.
- W2322753818 crossrefType "journal-article" @default.
- W2322753818 hasAuthorship W2322753818A5018120485 @default.
- W2322753818 hasAuthorship W2322753818A5034087287 @default.
- W2322753818 hasAuthorship W2322753818A5040082277 @default.
- W2322753818 hasAuthorship W2322753818A5078648606 @default.
- W2322753818 hasAuthorship W2322753818A5083170125 @default.
- W2322753818 hasAuthorship W2322753818A5083487213 @default.
- W2322753818 hasConcept C120665830 @default.
- W2322753818 hasConcept C121332964 @default.
- W2322753818 hasConcept C121608353 @default.
- W2322753818 hasConcept C126322002 @default.
- W2322753818 hasConcept C142724271 @default.
- W2322753818 hasConcept C143998085 @default.
- W2322753818 hasConcept C144301174 @default.
- W2322753818 hasConcept C2779013556 @default.
- W2322753818 hasConcept C38180746 @default.
- W2322753818 hasConcept C44249647 @default.
- W2322753818 hasConcept C61511704 @default.
- W2322753818 hasConcept C71924100 @default.
- W2322753818 hasConcept C90924648 @default.
- W2322753818 hasConceptScore W2322753818C120665830 @default.
- W2322753818 hasConceptScore W2322753818C121332964 @default.
- W2322753818 hasConceptScore W2322753818C121608353 @default.
- W2322753818 hasConceptScore W2322753818C126322002 @default.
- W2322753818 hasConceptScore W2322753818C142724271 @default.
- W2322753818 hasConceptScore W2322753818C143998085 @default.
- W2322753818 hasConceptScore W2322753818C144301174 @default.
- W2322753818 hasConceptScore W2322753818C2779013556 @default.
- W2322753818 hasConceptScore W2322753818C38180746 @default.
- W2322753818 hasConceptScore W2322753818C44249647 @default.
- W2322753818 hasConceptScore W2322753818C61511704 @default.
- W2322753818 hasConceptScore W2322753818C71924100 @default.
- W2322753818 hasConceptScore W2322753818C90924648 @default.
- W2322753818 hasIssue "3" @default.
- W2322753818 hasLocation W23227538181 @default.
- W2322753818 hasLocation W23227538182 @default.
- W2322753818 hasOpenAccess W2322753818 @default.
- W2322753818 hasPrimaryLocation W23227538181 @default.
- W2322753818 hasRelatedWork W1580426574 @default.
- W2322753818 hasRelatedWork W1984877488 @default.
- W2322753818 hasRelatedWork W2089620537 @default.
- W2322753818 hasRelatedWork W2275480158 @default.
- W2322753818 hasRelatedWork W2323950372 @default.
- W2322753818 hasRelatedWork W2371214482 @default.
- W2322753818 hasRelatedWork W2407004706 @default.
- W2322753818 hasRelatedWork W2929987155 @default.
- W2322753818 hasRelatedWork W3095306390 @default.
- W2322753818 hasRelatedWork W4238089809 @default.
- W2322753818 hasVolume "75" @default.
- W2322753818 isParatext "false" @default.
- W2322753818 isRetracted "false" @default.
- W2322753818 magId "2322753818" @default.
- W2322753818 workType "article" @default.