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• W2322797046 abstract "Objective: Organ preservation using a machine perfusion is one of the effective solutions for organ shortage of transplantation. There are various researches of it for lung, kidney, and liver. For kidney transplantation, there are some commercial clinical systems for a preservation using the hypothermic machine perfusion (HMP) instead of the cold storage (CS). The hypothermic perfusion is common approach to preserve the organ reduced oxygen and nutrition consumption. And there are some studies using a normothermic perfusion with maintenance oxygen and with a heat control to keep normothermic condition. Maintenance of the temperature is very important to preserve the organ viability. There are nothing established perfusion machine systems with the temperature controlled perfusate. Furthermore, there are nothing enough knowledge of the normothermic and the temperature controlled perfusion. In this study, a newly developed MP preservation system is introduced. This system is not useful only for liver preservation but also for the evaluation of graft viability and recovery functions during MP. This novel method has been proposed for preservation of porcine liver grafts using a temperature-controlled perfusion model. Method: This novel system is able to control the temperature of perfusate during preservation. This system has a function of the evaluation of the graft is important to adopt critical grafts. This system has circulating circuits for the portal vein (PV) and hepatic artery (HA). These circuits can control respectively and non-pulsatile flow for PV and pulsatile flow for HA were maintained in this study. And perfusate controlled temperature and constituent is supplied during preservation. An oxygenator was installed in the HA circuit. Pressure and flow rate of both circuits are measured and temperatures of the perfusate and the graft were recorded. Some cumulative releases were measured. An experiment was performed on livers obtained from pigs. The warm ischemia time (WIT) of the liver was controlled with operative procedures. In this study, three types of the perfusion temperature model was demonstrated: the hypothermic perfusion model, the normal temperature perfusion model (20-25C), and the controlled temperature perfusion model(from 4 to 25C). This model included 2 h of conventional CS and 60 min of WIT. The special modified University of Wisconsin solution for the transition of temperature was used. Results and discussion: The pressure transitions in HA during MP preservation and the cumulative release of LDH in the case of the temperature-controlled perfusion condition (n = 3) shows has some advantages. The temperature of the perfusate and the graft are increased gradually during perfusion. In the case of the temperature-controlled perfusion condition result showed a sudden decrease in pressure in the initial stage of perfusion. These pressure trends may indicate not only temperature effects on viscosity and some physical parameters but also the response of the hepatic lobules. These results support the temperature-controlled perfusion has advantage of preservation. Furthermore, the temperature controlled machine perfusion system must be effective preservation tool for liver transplantation." @default.
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• W2322797046 date "2012-11-01" @default.
• W2322797046 modified "2023-09-26" @default.
• W2322797046 title "Temperature Controlled Machine Perfusion System for Liver" @default.
• W2322797046 doi "https://doi.org/10.1097/00007890-201211271-00562" @default.
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