FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2322842938> ?p ?o ?g. }

• W2322842938 abstract "G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways. Different GPCRs may also interact to form heteromers that are novel signaling units. Despite the exponential growth in the number of solved GPCR crystal structures, the structural properties of heteromers remain unknown. We used single-particle tracking experiments in cells expressing functional adenosine A1-A2A receptors fused to fluorescent proteins to show the loss of Brownian movement of the A1 receptor in the presence of the A2A receptor, and a preponderance of cell surface 2:2 receptor heteromers (dimer of dimers). Using computer modeling, aided by bioluminescence resonance energy transfer assays to monitor receptor homomerization and heteromerization and G-protein coupling, we predict the interacting interfaces and propose a quaternary structure of the GPCR tetramer in complex with two G proteins. The combination of results points to a molecular architecture formed by a rhombus-shaped heterotetramer, which is bound to two different interacting heterotrimeric G proteins (Gi and Gs). These novel results constitute an important advance in understanding the molecular intricacies involved in GPCR function." @default.
• W2322842938 created "2016-06-24" @default.
• W2322842938 creator A5013842852 @default.
• W2322842938 creator A5014576744 @default.
• W2322842938 creator A5020432935 @default.
• W2322842938 creator A5026462548 @default.
• W2322842938 creator A5037871513 @default.
• W2322842938 creator A5040292972 @default.
• W2322842938 creator A5041672678 @default.
• W2322842938 creator A5045673110 @default.
• W2322842938 creator A5046444163 @default.
• W2322842938 creator A5053140772 @default.
• W2322842938 creator A5056422298 @default.
• W2322842938 creator A5064609300 @default.
• W2322842938 creator A5075905205 @default.
• W2322842938 creator A5078699014 @default.
• W2322842938 creator A5086346963 @default.
• W2322842938 date "2016-04-05" @default.
• W2322842938 modified "2023-10-15" @default.
• W2322842938 title "Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs" @default.
• W2322842938 cites W1833104430 @default.
• W2322842938 cites W1913276139 @default.
• W2322842938 cites W1965064544 @default.
• W2322842938 cites W1966386031 @default.
• W2322842938 cites W1970613671 @default.
• W2322842938 cites W1971256251 @default.
• W2322842938 cites W1973245565 @default.
• W2322842938 cites W1975670650 @default.
• W2322842938 cites W1993325325 @default.
• W2322842938 cites W2003872694 @default.
• W2322842938 cites W2017713787 @default.
• W2322842938 cites W2021580832 @default.
• W2322842938 cites W2021722027 @default.
• W2322842938 cites W2025951927 @default.
• W2322842938 cites W2027159196 @default.
• W2322842938 cites W2029021490 @default.
• W2322842938 cites W2033118734 @default.
• W2322842938 cites W2039399096 @default.
• W2322842938 cites W2041211150 @default.
• W2322842938 cites W2045019019 @default.
• W2322842938 cites W2053742583 @default.
• W2322842938 cites W2064664612 @default.
• W2322842938 cites W2081571345 @default.
• W2322842938 cites W2083075330 @default.
• W2322842938 cites W2083725367 @default.
• W2322842938 cites W2086889423 @default.
• W2322842938 cites W2094454635 @default.
• W2322842938 cites W2096327613 @default.
• W2322842938 cites W2100147128 @default.
• W2322842938 cites W2105840785 @default.
• W2322842938 cites W2106307937 @default.
• W2322842938 cites W2114520383 @default.
• W2322842938 cites W2133251633 @default.
• W2322842938 cites W2141956263 @default.
• W2322842938 cites W2152714052 @default.
• W2322842938 cites W2160544821 @default.
• W2322842938 cites W2167857702 @default.
• W2322842938 cites W2168634451 @default.
• W2322842938 cites W2321951077 @default.
• W2322842938 doi "https://doi.org/10.1186/s12915-016-0247-4" @default.
• W2322842938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4822319" @default.
• W2322842938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27048449" @default.
• W2322842938 hasPublicationYear "2016" @default.
• W2322842938 type Work @default.
• W2322842938 sameAs 2322842938 @default.
• W2322842938 citedByCount "96" @default.
• W2322842938 countsByYear W23228429382016 @default.
• W2322842938 countsByYear W23228429382017 @default.
• W2322842938 countsByYear W23228429382018 @default.
• W2322842938 countsByYear W23228429382019 @default.
• W2322842938 countsByYear W23228429382020 @default.
• W2322842938 countsByYear W23228429382021 @default.
• W2322842938 countsByYear W23228429382022 @default.
• W2322842938 countsByYear W23228429382023 @default.
• W2322842938 crossrefType "journal-article" @default.
• W2322842938 hasAuthorship W2322842938A5013842852 @default.
• W2322842938 hasAuthorship W2322842938A5014576744 @default.
• W2322842938 hasAuthorship W2322842938A5020432935 @default.
• W2322842938 hasAuthorship W2322842938A5026462548 @default.
• W2322842938 hasAuthorship W2322842938A5037871513 @default.
• W2322842938 hasAuthorship W2322842938A5040292972 @default.
• W2322842938 hasAuthorship W2322842938A5041672678 @default.
• W2322842938 hasAuthorship W2322842938A5045673110 @default.
• W2322842938 hasAuthorship W2322842938A5046444163 @default.
• W2322842938 hasAuthorship W2322842938A5053140772 @default.
• W2322842938 hasAuthorship W2322842938A5056422298 @default.
• W2322842938 hasAuthorship W2322842938A5064609300 @default.
• W2322842938 hasAuthorship W2322842938A5075905205 @default.
• W2322842938 hasAuthorship W2322842938A5078699014 @default.
• W2322842938 hasAuthorship W2322842938A5086346963 @default.
• W2322842938 hasBestOaLocation W23228429381 @default.
• W2322842938 hasConcept C104292427 @default.
• W2322842938 hasConcept C104317684 @default.
• W2322842938 hasConcept C12554922 @default.
• W2322842938 hasConcept C135285700 @default.
• W2322842938 hasConcept C139407321 @default.
• W2322842938 hasConcept C170493617 @default.
• W2322842938 hasConcept C2780126713 @default.
• W2322842938 hasConcept C55493867 @default.
• W2322842938 hasConcept C78254988 @default.

• next