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- W2322843920 abstract "To determine the maximal tolerated dose and the dose-limiting toxicity of hydroxycamptothecin (HCPT) concurrently combined with three-dimensional conformal radiation therapy (3DCRT) for unresectable or locally relapsed rectal cancer. Twenty-two patients with rectal cancer were enrolled into phase I study on 2004-2007 years. HCPT was intravenously administered concurrently with 3DCRT weekly or twice a week, dose given from 6,8,10mg/m2 and 4,6,8,10 mg/m2, respectively. Total radiation dose of DT50 Gy was delivered to the whole pelvis in a fraction of 2 Gy per day for 5 weeks, with 10-16 Gy subsequent boost to tumor area. Dose-limiting toxicities (DLT) were defined as grade 3 or higher non-hematologic toxicity or grade 4 hematologic toxicity. In the twice a week group, DLTs of grade 3 diarrhea were observed in 2 patient treated at dose of 6 mg/m2. In the weekly group, DLTs of grade 3 diarrhea and radiation-induced dermatitis were observed in 1 patient at dose of 8 mg/m2, and were not observed in the next 3 patients at the same dose level. However, at dose of 10 mg/m2, 2 patients had grade 3 diarrhea or nausea. The 5-year overall survival was 23%, with median survival time of 18 months. HCPT given concurrently with 3DCRT is safe and tolerable for patients with unresectable or locally relapsed rectal cancer. Either 8 mg/m2 weekly or 4 mg/m2 twice a week can be recommended for further study. The dose-limiting toxicities are grade 3 diarrhea, nausea and radiation-induced dermatitis." @default.
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- W2322843920 date "2012-11-01" @default.
- W2322843920 modified "2023-09-26" @default.
- W2322843920 title "Phase I Clinical Study of Concurrent Chemoradiation With Hydroxycamptothecin for Unresectable or Locally Relapsed Rectal Cancer" @default.
- W2322843920 doi "https://doi.org/10.1016/j.ijrobp.2012.07.898" @default.
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