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- W2322856892 abstract "This prospective observational study was designed to assess the effects of opioids and other pain medications in fibromyalgia treatment. Data were collected from patients via physician surveys, office visits and telephone interviews at baseline, 1, 3, 6, and 12 months. Patients were classified into mutually exclusive cohorts based on their use of opioids (any non-tramadol opioids; N=412), tramadol (tramadol but non-opioids; N=232), or non-opioids (use of neither opioids nor tramadol; N=1056) at baseline. Propensity score matching was used to construct matched-cohorts with similar demographics, and clinical and economic characteristics, including 1) opioids vs. tramadol; 2) opioids vs. non-opioids; and 3) tramadol vs. non-opioids. Repeated measures models were used to assess patient outcome variables over time, including Brief Pain Inventory (BPI), Fibromyalgia Impact Questionnaire (FIQ), depression (8-item Patient Health Questionnaire), anxiety (Generalized Anxiety Disorder 7-item scale), disability (Sheehan Disability Scale), and insomnia (Insomnia Severity Index). Repeated measures logistic regression was used to assess resource utilization over time. Of the 1,700 baseline study participants, most (62.1%) took non-opioids followed by opioids (24.2%), and tramadol (13.6%). Compared with the opioids cohort, the non-opioids cohort demonstrated statistically significant greater reductions (p<0.05) in BPI, FIQ, depression, disability and insomnia; the tramadol cohort showed significant reductions for FIQ and insomnia. Reductions in pain severity and anxiety didn't differ significantly among cohorts. Compared with opioids cohort, patients in tramadol and non-opioids cohorts were less likely to receive help from non-paid caregiver, and patients in tramadol cohort were less likely to have outpatient visits. Among patients taking opioids at baseline (N=412), 30.3% discontinued opioids. Few significant differences were found between tramadol and non-opioids cohorts across outcomes. While pain severity was reduced over time in all cohorts, opioids users showed less improvement in interference from pain, depression, and insomnia symptoms. Support provided by Eli Lilly and Company." @default.
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- W2322856892 date "2012-04-01" @default.
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- W2322856892 title "The long term evaluation of opioids in fibromyalgia treatment" @default.
- W2322856892 doi "https://doi.org/10.1016/j.jpain.2012.01.332" @default.
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