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• W2322869353 abstract "We examined 5-hydroxytryptamine 1A (5-HT1A) receptor-mediated modulation of glutamatergic transmission in rat medullary dorsal horn neurons using a conventional whole-cell patch clamp technique. 5-HT reversibly and concentration dependently decreased the amplitude of glutamatergic excitatory postsynaptic currents and increased the paired-pulse ratio, indicating that 5-HT acts presynaptically to reduce glutamate release from primary afferents. The 5-HT-induced inhibition of excitatory postsynaptic currents was partially occluded by NAN-190, a 5-HT1A receptor antagonist, and mimicked by 8-OH-DPAT, a 5-HT1A receptor agonist. Our results suggest that presynaptic 5-HT1A receptors inhibit glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons, and thus in addition to other 5-HT1 receptor subtypes, 5-HT1A receptors could be a potential target for treatment of pain from orofacial tissues." @default.
• W2322869353 created "2016-06-24" @default.
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• W2322869353 date "2013-05-29" @default.
• W2322869353 modified "2023-10-18" @default.
• W2322869353 title "5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons" @default.
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• W2322869353 doi "https://doi.org/10.1097/wnr.0b013e3283614cbf" @default.
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