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• W2322914892 abstract "Purpose.: Tear hyperosmolarity is a ubiquitous feature of dry-eye disease. Although dry-eye patients' sensitivity to cooling is well known, the effects of tear hyperosmolarity on a small amount of cooling in the corneal nerves have not been quantitatively examined. Recently reported corneal afferents, high-threshold cold sensitive plus dry-sensitive (HT-CS + DS) neurons, in rats is normally excited by strong (>4°C) cooling of the cornea, which, when applied to healthy humans, evokes the sensation of discomfort. However, corneal cooling measured between blinks does not exceed 2°C normally. Thus, we sought to determine if these nociceptors could be sensitized by hyperosmolar tears such that they are now activated by small cooling of the ocular surface. Methods.: Trigeminal ganglion neurons innervating the cornea were extracellularly recorded in isoflurane-anesthetized rats. The responses of single corneal neurons to cooling stimuli presented in the presence of hyperosmolar (350–800 mOsm NaCl) tears were examined. Results.: The HT-CS + DS neurons with thresholds averaging 4°C cooling responded to cooling stimuli presented after 15 minutes of hyperosmolar tears with thresholds of less than 1°C. The response magnitudes also were enhanced so that the responses to small (2°C) cooling emerged, where none was observed before. Conclusions.: These results demonstrate that after exposure to hyperosmolar tears, these nociceptive corneal neurons now begin to respond to the slight cooling normally encountered between blinks, enabling the painful information to be carried to the brain, which could explain the cooling-evoked discomfort in dry eye patients." @default.
• W2322914892 created "2016-06-24" @default.
• W2322914892 creator A5034238246 @default.
• W2322914892 creator A5075863601 @default.
• W2322914892 date "2014-09-15" @default.
• W2322914892 modified "2023-09-30" @default.
• W2322914892 title "Hyperosmolar Tears Enhance Cooling Sensitivity of the Corneal Nerves in Rats: Possible Neural Basis for Cold-Induced Dry Eye Pain" @default.
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• W2322914892 doi "https://doi.org/10.1167/iovs.14-14642" @default.
• W2322914892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4165368" @default.
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• W2322914892 hasPublicationYear "2014" @default.
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