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- W2322921656 abstract "The decline of the most abundant circulating adrenal steroid hormone in humans, dehydroepiandrosterone (DHEA), produced by the adrenal cortex and the Central Nervous System (CNS), with advancing age, has been linked to the development of neurodegenerative diseases. Microglial cells, the CNS-resident macrophages, are prone to a macrophages-like polarization: in their resting state they appear in a ramified “M2” phenotype-like state, maintaining CNS tissue homeostasis, while upon activation, they acquire a pro-inflammatory “M1”-like phenotype. Recently we have identified DHEA as a novel ligand of the Nerve Growth Factor Tropomyosin Related kinase A (TrkA). Furthermore we have synthesized a DHEA analogue, called BNN27 that cannot be converted to androgen or estrogen, which also binds to and activates NGF receptors." @default.
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- W2322921656 date "2014-03-05" @default.
- W2322921656 modified "2023-10-14" @default.
- W2322921656 title "Dehydroepiandrosterone and a synthetic analogue regulate microglial cell polarization" @default.
- W2322921656 doi "https://doi.org/10.1055/s-0034-1371978" @default.
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