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- W2322943044 abstract "Background: Emerging evidence suggests a link between cardiovascular disease, osteoporosis and increased fracture risk. Given the emerging epidemic of atrial fibrillation (AF), a condition sharing common etiologic mechanisms with other cardiovascular diseases, we used a population-based cohort study to examine whether incident AF is associated with an excess risk of subsequent fracture. Methods: Consecutive patients presenting with incident AF to the Royal Adelaide Hospital between 2001 and 2011 were identified. All patients with and without incident AF were followed up to the most recent clinical contact (last follow-up July 2011). A multivariate Cox proportional hazards model was employed to model time to hip fracture occurrence. Age and gender were fitted as time-invariant covariates, while AF and other cardiovascular diseases were fitted as time-varying covariates. Results: The study included 90,429 subjects: 4593 cases with previous AF, 5625 cases with incident AF during the study period and 80,211 cases without previous or incident AF. Independent of other cardiovascular diseases included in the multivariate model, the risk of hip fracture occurrence was 58.1% higher amongst patients diagnosed with incident AF than those not diagnosed with incident AF (hazard ratio [HR] 1.581, 95% confidence interval [CI] 1.399 to 1.787). Other covariates that were risk factors for hip fracture occurrence included age (HR 1.076, 95% CI 1.071–1.081), female sex (HR 1.605, 95% CI 1.450-1.777), hypertension (HR 1.215, 95% 1.091–1.353) and heart failure (HR 1.688, 95% CI 1.475–1.932). Conclusions: In this population-based cohort study, we found a large excess risk of hip fracture after incident AF. Given that hip fracture is a devastating event that causes major morbidity and mortality, and that the incidence of AF is exponentially increasing in our ageing population, our findings have important public health implications and require further study." @default.
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- W2322943044 date "2012-01-01" @default.
- W2322943044 modified "2023-09-26" @default.
- W2322943044 title "Atrial Fibrillation is Associated with an Increase in Fracture Risk: A Population-Based Cohort Study" @default.
- W2322943044 doi "https://doi.org/10.1016/j.hlc.2012.05.749" @default.
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