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- W2322947818 endingPage "429" @default.
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- W2322947818 abstract "Cocaine use is associated with high levels of impulsive choice (greater discounting of delayed rewards) in humans, but the cause/effect relationships between cocaine use and impulsive choice are not fully understood. In previous work, we found that both experimenter- and self-administration of fixed quantities of cocaine caused lasting increases in impulsive choice in rats. The present study extended these findings by taking into account baseline impulsive choice prior to self-administration and by allowing rats free access to cocaine. Male Long-Evans rats were trained in a delay discounting task in which they made discrete-trial choices between small immediate and large delayed food rewards. Half of the rats were then implanted with intravenous catheters and, following recovery, allowed to self-administer cocaine HCl (1.0 mg/kg/infusion) in 6-hr sessions over 14 days. Control rats orally self-administered a sucrose solution under similar conditions. Upon completion of self-administration, rats remained abstinent for 3 weeks before retesting in the delay discounting task. Cocaine and control groups did not differ prior to self-administration, but afterward, the cocaine group showed greater impulsive choice (fewer choices of large, delayed rewards) than controls. Additional analyses revealed that the effects of cocaine on impulsive choice were intake-dependent; rats classified as low intake did not differ from controls, whereas rats classified as high intake were significantly more impulsive than both controls and their precocaine baseline. These findings are consistent with the idea that cocaine-induced, pharmacologically based neural adaptations promote the development of impulsive decision making." @default.
- W2322947818 created "2016-06-24" @default.
- W2322947818 creator A5001236329 @default.
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- W2322947818 creator A5083927561 @default.
- W2322947818 creator A5086981091 @default.
- W2322947818 date "2014-01-01" @default.
- W2322947818 modified "2023-10-15" @default.
- W2322947818 title "Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task." @default.
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