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• W2322950710 abstract "Blood fluke of the genus <i>Schistosoma</i> are the etiological agents of human schistosomiasis, an important neglected tropical disease that afflicts over 200 million people worldwide. The treatment for this disease relies heavily on a single drug, praziquantel. Recent reports of praziquantel resistance raise concerns about future control of the disease and show the importance of developing new antischistosomal drugs. Currently, natural products have been a good source for drug development. (+)-Limonene epoxide is a mixture of <i>cis</i> and <i>trans</i> isomers found in many plants. Here, we report the <i>in vitro</i> effect of this natural compound on the survival time of <i>Schistosoma mansoni</i> adult worms. In addition, we examined alterations on the tegumental surface of adult schistosomes by means of confocal laser scanning microscopy. The effects of (+)-limonene epoxide at 25 µg/mL on <i>S. mansoni</i> adult worms were similar to those of the positive control (praziquantel), with reduction in motility and death of all worms after 120 h. Confocal laser scanning microscopy revealed that (+)-limonene epoxide-mediated worm killing was associated with tegumental destruction. Our results, along with the low toxicity of the (+)-limonene epoxide, suggest that this natural compound might be promising for the development of new schistosomicidal agents." @default.
• W2322950710 created "2016-06-24" @default.
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• W2322950710 date "2013-02-13" @default.
• W2322950710 modified "2023-10-06" @default.
• W2322950710 title "Anthelmintic Activity of the Natural Compound (+)-Limonene Epoxide against Schistosoma mansoni" @default.
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• W2322950710 doi "https://doi.org/10.1055/s-0032-1328173" @default.
• W2322950710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23408270" @default.
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