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• W2322969475 endingPage "10546" @default.
• W2322969475 startingPage "10537" @default.
• W2322969475 abstract "Five-membered exocyclic DNA adducts are biologically very significant because of their potential to block DNA replication and transcription. N(2),3-Ethenoguanine (N(2,3)-εG) has been identified in the liver DNA of vinyl chloride-exposed rats as a five-membered DNA adduct. Singer et al. ( Carcinogenesis 1987 , 8 , 745 - 747 ) reported that the misincorporation of thymine (T), with two hydrogen bonds to N(2,3)-εG, represents the mutagenic event. Although the base-pairing specificity and mode of misincorporation have been studied experimentally for the N(2),3-ethenoguanine adduct, molecular-level information is not yet clear. In this study, we have considered all four different DNA nucleotides paired with the N(2),3-ethenoguanine adduct for model calculations toward the determination of base-pairing specificity. To provide insight into the mutagenic process of DNA damage based on geometric characteristics and electronic properties, the B3LYP and M06 methods were employed for these model calculations. Single-point energy calculations at the MP2/6-311++G** level on the corresponding optimized geometries were also carried out to better estimate the hydrogen-bonding strengths. The polarizable conductor calculation model (CPCM), which accounts for the overall polarizability of the solvent, was also employed. The computed reaction enthalpy values lie in the order εG-G(2) (10.3 kcal/mol) > εG-G(4) (9.6 kcal/mol) > εG-T(4) (9.2 kcal/mol) > εG-G(1) (9.1 kcal/mol) > εG-A(5) (8.2 kcal/mol) > εG-C(2) (7.9 kcal/mol) at the M06 level, which indicates that guanine and thymine are most favorable for mispairing with the N(2),3-ethenoguanine adduct." @default.
• W2322969475 created "2016-06-24" @default.
• W2322969475 creator A5015086964 @default.
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• W2322969475 date "2011-08-11" @default.
• W2322969475 modified "2023-10-17" @default.
• W2322969475 title "Model Calculations for the Misincorporation of Nucleotides Opposite Five-Membered Exocyclic DNA Adduct: <i>N</i>²,3-Ethenoguanine" @default.
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• W2322969475 cites W1966666947 @default.
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• W2322969475 cites W1973136693 @default.
• W2322969475 cites W1974331509 @default.
• W2322969475 cites W1974667766 @default.
• W2322969475 cites W1974959985 @default.
• W2322969475 cites W1979390689 @default.
• W2322969475 cites W1979451521 @default.
• W2322969475 cites W1981353016 @default.
• W2322969475 cites W1988902684 @default.
• W2322969475 cites W1989375229 @default.
• W2322969475 cites W1993277203 @default.
• W2322969475 cites W1994404303 @default.
• W2322969475 cites W1997340274 @default.
• W2322969475 cites W1998201601 @default.
• W2322969475 cites W2016546148 @default.
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• W2322969475 doi "https://doi.org/10.1021/jp202738v" @default.
• W2322969475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21776999" @default.
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