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• W2322974158 abstract "You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology II1 Apr 2016MP89-14 CATEGORY III PROSTATITIS AFFECT PREMATURE EJACULATION THROUGH BRAIN AND SPINAL CORD SEROTONIN SYSTEM: A PRELIMINARY STUDY Yadong Zhang, Tao Zheng, Xiangan Tu, Qiyun Yang, Kunlong Lv, Minkuan Zhou, Kai Xia, Xiangzhou Sun, and Chunhua Deng Yadong ZhangYadong Zhang More articles by this author , Tao ZhengTao Zheng More articles by this author , Xiangan TuXiangan Tu More articles by this author , Qiyun YangQiyun Yang More articles by this author , Kunlong LvKunlong Lv More articles by this author , Minkuan ZhouMinkuan Zhou More articles by this author , Kai XiaKai Xia More articles by this author , Xiangzhou SunXiangzhou Sun More articles by this author , and Chunhua DengChunhua Deng More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2475AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To explore the preliminary mechanism of premature ejaculation in rat with category III prostatitis, or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS We establish rat model of experimental autoimmune prostatitis (EAP) by subcutaneous multiple point's injection of male prostate gland extract emulsified in an equal volume of Freund’s adjuvant at the 0 and 21th day. The behavioral change and the sexual behavior was investigated. Then, we We took out the hippocampus tissue, T13-L2 and L5- S2 spinal cord tissue after perfusion, and detected the levels of 5-HT, 5-HT1A receptor, 5-HT2C receptor and SERT in these tissues by immunohistochemical staining. The levels of 5-HT, 5-HT1A receptor, 5-HT2C receptor and SERT in the remaining rats were detected by Western Blot. RESULTS The EAP model was built successfully. Serum IL-1ß and TNF-a levels in the model were significantly higher than control (p<0.01). In the copulatory test, compared with normal control group, mount frequency (MF), intromission frequency (IF) and ejaculation frequency (EF) in the model group were significantly decreased (p <0.05); mount latency (ML), intromission latency (IL) and postejaculatory interval (PEI) in the model group were significantly shortened (p <0.05); ejaculation latency (EL) in the model group was significantly significantly prolonged (p <0.05). In hippocampus tissue, 5-HT levels in the model were significantly lower than normal (p<0.05), whereas 5-HT1A, 5-HT2C and SERT levels in the model were significantly higher than normal (p<0.05). In T13-L2 spinal cord tissue, 5-HT levels in the model were significantly lower (p<0.05), 5-HT1A receptor levels in the model were significantly increased (p<0.05). In L5-S2 spinal cord tissues, 5-HT levels in the model were significantly lower (p<0.05), while the 5-HT1A, 5-HT2C and SERT levels in the model increased slightly, but the differences in 5-HT1A, 5-HT2C and SERT levels between the two group were statistically significant (p<0.05). CONCLUSIONS We have successfully established a rat model of EAP that exhibited characteristics of depression, decreased libido and premature ejaculation. EAP may affect PE in rat through brain and spinal cord 5-HT neurotransmitter system. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1142 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Yadong Zhang More articles by this author Tao Zheng More articles by this author Xiangan Tu More articles by this author Qiyun Yang More articles by this author Kunlong Lv More articles by this author Minkuan Zhou More articles by this author Kai Xia More articles by this author Xiangzhou Sun More articles by this author Chunhua Deng More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2322974158 title "MP89-14 CATEGORY III PROSTATITIS AFFECT PREMATURE EJACULATION THROUGH BRAIN AND SPINAL CORD SEROTONIN SYSTEM: A PRELIMINARY STUDY" @default.
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