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- W2322977850 abstract "Depressive symptoms during pregnancy are associated with elevations in proinflammatory cytokines and poor maternal-infant health. The purpose of this study was to investigate if exposure to adverse experiences during childhood increases inflammation-related depressive symptoms during pregnancy and risk for low infant birth weight. A diverse sample of women ( N = 53) with uncomplicated pregnancies completed measures of perceived stress, mood, anxiety, social support, and depressive symptoms during their second trimester. Blood was obtained for cytokine analysis. Childhood adversity was measured by administering the Childhood Trauma Questionnaire. Findings revealed that pregnant women reporting more depressive symptoms had higher plasma TNF-α levels. Furthermore, women with greater exposure to childhood adversity had greater perceived stress, more depressive symptoms, and higher plasma TNF-α than women reporting little or no childhood adversity. Moreover, childhood adversity moderated the relationship between TNF-α and depressive symptoms, such that high adversity coupled with high TNF-α levels were associated with greater depressive symptoms. Both greater childhood adversity and increased plasma TNF-α correlated with lower infant birth weight. In this sample, low-income African American women (AAW) reported more childhood adversity, more depressive symptoms, and exhibited higher TNF-α levels compared to White women. AAW also reported less social support, amplifying depressive risk during pregnancy. These data identify childhood adversity to intensify risk for maternal depressive symptoms and infant low birth weight, which may be driven by proinflammatory cytokines." @default.
- W2322977850 created "2016-06-24" @default.
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- W2322977850 date "2014-09-01" @default.
- W2322977850 modified "2023-09-25" @default.
- W2322977850 title "125. Childhood adversity increases risk for depressive symptoms and elevated proinflammatory cytokines during pregnancy" @default.
- W2322977850 doi "https://doi.org/10.1016/j.bbi.2014.06.145" @default.
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