Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323006359> ?p ?o ?g. }
- W2323006359 endingPage "1780" @default.
- W2323006359 startingPage "1767" @default.
- W2323006359 abstract "Models of the maintenance of genetic variance in a polygenic trait have usually assumed that population size is infinite and that selection is weak. Consequently, they will overestimate the amount of variation maintained in finite populations. I derive approximations for the equilibrium genetic variance, in finite populations under weak stabilizing selection for triallelic loci and for an infinite “rare alleles” model. These are compared to results for neutral characters, to the “Gaussian allelic” model, and to Wright's approximation for a biallelic locus under arbitrary selection pressures. For a variety of parameter values, the three-allele, Gaussian, and Wrightian approximations all converge on the neutral model when population size is small. As expected, far less equilibrium genetic variance can be maintained if effective population size, N, is on the order of a few hundred than if N is infinite. All of the models predict that comparisons among populations with N less than about 104 should show substantial differences in . While it is easier to maintain absolute when alleles interact to yield dominance or overdominance for fitness, less additivity also makes more susceptible to differences in N. I argue that experimental data do not seem to reflect the predicted degree of relationship between N and . This calls into question the ability of mutation-selection balance or simple balancing selection to explain observed . The dependence of on N could be used to test the adequacy of mutation-selection balance models." @default.
- W2323006359 created "2016-06-24" @default.
- W2323006359 creator A5066399491 @default.
- W2323006359 date "1989-12-01" @default.
- W2323006359 modified "2023-10-11" @default.
- W2323006359 title "THE MAINTENANCE OF POLYGENIC VARIATION IN FINITE POPULATIONS" @default.
- W2323006359 cites W1559579788 @default.
- W2323006359 cites W1827107635 @default.
- W2323006359 cites W1857512534 @default.
- W2323006359 cites W1869520791 @default.
- W2323006359 cites W1884125334 @default.
- W2323006359 cites W1897869592 @default.
- W2323006359 cites W1931969146 @default.
- W2323006359 cites W1942547768 @default.
- W2323006359 cites W1964676174 @default.
- W2323006359 cites W1972106104 @default.
- W2323006359 cites W1975894731 @default.
- W2323006359 cites W1977718325 @default.
- W2323006359 cites W1978697143 @default.
- W2323006359 cites W1990508112 @default.
- W2323006359 cites W1991285631 @default.
- W2323006359 cites W1992474892 @default.
- W2323006359 cites W1993830697 @default.
- W2323006359 cites W1994702080 @default.
- W2323006359 cites W2009035268 @default.
- W2323006359 cites W2020872336 @default.
- W2323006359 cites W2025333648 @default.
- W2323006359 cites W2037015265 @default.
- W2323006359 cites W2037383618 @default.
- W2323006359 cites W2045402725 @default.
- W2323006359 cites W2053990481 @default.
- W2323006359 cites W2061851999 @default.
- W2323006359 cites W2090515554 @default.
- W2323006359 cites W2092549911 @default.
- W2323006359 cites W2105621710 @default.
- W2323006359 cites W2119500014 @default.
- W2323006359 cites W2121487534 @default.
- W2323006359 cites W2123897090 @default.
- W2323006359 cites W2123942615 @default.
- W2323006359 cites W2124899473 @default.
- W2323006359 cites W2133999074 @default.
- W2323006359 cites W2134290430 @default.
- W2323006359 cites W2137259417 @default.
- W2323006359 cites W2138347380 @default.
- W2323006359 cites W2143673411 @default.
- W2323006359 cites W2146151486 @default.
- W2323006359 cites W2159707462 @default.
- W2323006359 cites W2169825210 @default.
- W2323006359 cites W2313512588 @default.
- W2323006359 cites W2323460756 @default.
- W2323006359 cites W2327813589 @default.
- W2323006359 cites W1802901569 @default.
- W2323006359 doi "https://doi.org/10.1111/j.1558-5646.1989.tb02625.x" @default.
- W2323006359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28564343" @default.
- W2323006359 hasPublicationYear "1989" @default.
- W2323006359 type Work @default.
- W2323006359 sameAs 2323006359 @default.
- W2323006359 citedByCount "39" @default.
- W2323006359 countsByYear W23230063592014 @default.
- W2323006359 countsByYear W23230063592017 @default.
- W2323006359 countsByYear W23230063592019 @default.
- W2323006359 countsByYear W23230063592021 @default.
- W2323006359 countsByYear W23230063592023 @default.
- W2323006359 crossrefType "journal-article" @default.
- W2323006359 hasAuthorship W2323006359A5066399491 @default.
- W2323006359 hasBestOaLocation W23230063591 @default.
- W2323006359 hasConcept C104317684 @default.
- W2323006359 hasConcept C105795698 @default.
- W2323006359 hasConcept C106934330 @default.
- W2323006359 hasConcept C144024400 @default.
- W2323006359 hasConcept C149923435 @default.
- W2323006359 hasConcept C154945302 @default.
- W2323006359 hasConcept C180754005 @default.
- W2323006359 hasConcept C199360897 @default.
- W2323006359 hasConcept C2262138 @default.
- W2323006359 hasConcept C2908647359 @default.
- W2323006359 hasConcept C2992519594 @default.
- W2323006359 hasConcept C33923547 @default.
- W2323006359 hasConcept C3641667 @default.
- W2323006359 hasConcept C37233692 @default.
- W2323006359 hasConcept C41008148 @default.
- W2323006359 hasConcept C54355233 @default.
- W2323006359 hasConcept C68873052 @default.
- W2323006359 hasConcept C78458016 @default.
- W2323006359 hasConcept C81917197 @default.
- W2323006359 hasConcept C84597430 @default.
- W2323006359 hasConcept C86803240 @default.
- W2323006359 hasConceptScore W2323006359C104317684 @default.
- W2323006359 hasConceptScore W2323006359C105795698 @default.
- W2323006359 hasConceptScore W2323006359C106934330 @default.
- W2323006359 hasConceptScore W2323006359C144024400 @default.
- W2323006359 hasConceptScore W2323006359C149923435 @default.
- W2323006359 hasConceptScore W2323006359C154945302 @default.
- W2323006359 hasConceptScore W2323006359C180754005 @default.
- W2323006359 hasConceptScore W2323006359C199360897 @default.
- W2323006359 hasConceptScore W2323006359C2262138 @default.
- W2323006359 hasConceptScore W2323006359C2908647359 @default.
- W2323006359 hasConceptScore W2323006359C2992519594 @default.