FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323041537> ?p ?o ?g. }

• W2323041537 endingPage "519" @default.
• W2323041537 startingPage "514" @default.
• W2323041537 abstract "Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), shows substantial interindividual and intraindividual variability. It was recently shown that in vitro calcineurin inhibitors alter the bioavailability of MPA by dose-dependent inhibition of MPA glucuronidation. The authors retrospectively analyzed full 10-point profiles for both MPA and cyclosporine (CyA) in 23 pediatric patients receiving MMF and cyclosporine microemulsion (Neoral; Novartis Pharmaceuticals Canada; Dorval, Quebec, Canada). Mycophenolic acid was measured using a commercially available EMIT (Novartis Pharmaceuticals, Canada) assay. As the majority of patients were treated with low doses of cyclosporine after adding MMF, the area under the concentration–time curve (AUC) for cyclosporine showed a wide scatter ranging from 296 to 6400 ng × h/mL. The mean cyclosporine dose was 100 ± 76 mg/m 2 per day (range: 28 to 331). There was no correlation between MPA AUC and MPA dose, and there was substantial interindividual variation. However, there was a significant negative correlation between dose-normalized MPA AUC and cyclosporine AUC (r2 = 0.23, p < 0.0220). When dividing the MPA profiles into two groups (11 and 12 patients) with a CyA AUC less than or greater than 1600 ng × h/mL, there was a significantly higher 8-hour concentration in the patients with the lower CyA AUC, secondary to a higher second peak. The data demonstrate that the cyclosporine AUC is a determining factor for the MPA AUC and that MPA dose should be reduced when cyclosporine dose is reduced to achieve the same MPA AUC. The significantly higher peak in the group with a lower CyA profile supports the concept of a dose-dependent cyclosporine-induced inhibition of MPA glucuronidation." @default.
• W2323041537 created "2016-06-24" @default.
• W2323041537 creator A5007473317 @default.
• W2323041537 creator A5041338802 @default.
• W2323041537 creator A5042683401 @default.
• W2323041537 creator A5050854442 @default.
• W2323041537 date "2001-10-01" @default.
• W2323041537 modified "2023-10-06" @default.
• W2323041537 title "Effect of Cyclosporine on Mycophenolic Acid Area Under the Concentration–Time Curve in Pediatric Kidney Transplant Recipients" @default.
• W2323041537 cites W1891570058 @default.
• W2323041537 cites W1941314279 @default.
• W2323041537 cites W1964078380 @default.
• W2323041537 cites W1988798891 @default.
• W2323041537 cites W2011911900 @default.
• W2323041537 cites W2016100084 @default.
• W2323041537 cites W2016273346 @default.
• W2323041537 cites W2022411944 @default.
• W2323041537 cites W2025501899 @default.
• W2323041537 cites W2035719880 @default.
• W2323041537 cites W2064451454 @default.
• W2323041537 cites W2067353313 @default.
• W2323041537 cites W2073577235 @default.
• W2323041537 cites W2087666494 @default.
• W2323041537 cites W2149093312 @default.
• W2323041537 cites W2151455000 @default.
• W2323041537 cites W2159582645 @default.
• W2323041537 cites W2318497382 @default.
• W2323041537 cites W2318741379 @default.
• W2323041537 cites W2319376176 @default.
• W2323041537 cites W2410816895 @default.
• W2323041537 cites W2432265985 @default.
• W2323041537 cites W4230996310 @default.
• W2323041537 cites W4236530401 @default.
• W2323041537 cites W4248081342 @default.
• W2323041537 doi "https://doi.org/10.1097/00007691-200110000-00003" @default.
• W2323041537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11591896" @default.
• W2323041537 hasPublicationYear "2001" @default.
• W2323041537 type Work @default.
• W2323041537 sameAs 2323041537 @default.
• W2323041537 citedByCount "58" @default.
• W2323041537 countsByYear W23230415372012 @default.
• W2323041537 countsByYear W23230415372014 @default.
• W2323041537 countsByYear W23230415372015 @default.
• W2323041537 countsByYear W23230415372016 @default.
• W2323041537 countsByYear W23230415372017 @default.
• W2323041537 countsByYear W23230415372018 @default.
• W2323041537 countsByYear W23230415372019 @default.
• W2323041537 countsByYear W23230415372020 @default.
• W2323041537 countsByYear W23230415372021 @default.
• W2323041537 countsByYear W23230415372023 @default.
• W2323041537 crossrefType "journal-article" @default.
• W2323041537 hasAuthorship W2323041537A5007473317 @default.
• W2323041537 hasAuthorship W2323041537A5041338802 @default.
• W2323041537 hasAuthorship W2323041537A5042683401 @default.
• W2323041537 hasAuthorship W2323041537A5050854442 @default.
• W2323041537 hasConcept C112705442 @default.
• W2323041537 hasConcept C126322002 @default.
• W2323041537 hasConcept C126894567 @default.
• W2323041537 hasConcept C128057223 @default.
• W2323041537 hasConcept C181389837 @default.
• W2323041537 hasConcept C185592680 @default.
• W2323041537 hasConcept C2778033501 @default.
• W2323041537 hasConcept C2779528694 @default.
• W2323041537 hasConcept C2780272996 @default.
• W2323041537 hasConcept C2909675724 @default.
• W2323041537 hasConcept C2909935303 @default.
• W2323041537 hasConcept C2911091166 @default.
• W2323041537 hasConcept C31785415 @default.
• W2323041537 hasConcept C71924100 @default.
• W2323041537 hasConcept C76318530 @default.
• W2323041537 hasConcept C98274493 @default.
• W2323041537 hasConceptScore W2323041537C112705442 @default.
• W2323041537 hasConceptScore W2323041537C126322002 @default.
• W2323041537 hasConceptScore W2323041537C126894567 @default.
• W2323041537 hasConceptScore W2323041537C128057223 @default.
• W2323041537 hasConceptScore W2323041537C181389837 @default.
• W2323041537 hasConceptScore W2323041537C185592680 @default.
• W2323041537 hasConceptScore W2323041537C2778033501 @default.
• W2323041537 hasConceptScore W2323041537C2779528694 @default.
• W2323041537 hasConceptScore W2323041537C2780272996 @default.
• W2323041537 hasConceptScore W2323041537C2909675724 @default.
• W2323041537 hasConceptScore W2323041537C2909935303 @default.
• W2323041537 hasConceptScore W2323041537C2911091166 @default.
• W2323041537 hasConceptScore W2323041537C31785415 @default.
• W2323041537 hasConceptScore W2323041537C71924100 @default.
• W2323041537 hasConceptScore W2323041537C76318530 @default.
• W2323041537 hasConceptScore W2323041537C98274493 @default.
• W2323041537 hasIssue "5" @default.
• W2323041537 hasLocation W23230415371 @default.
• W2323041537 hasLocation W23230415372 @default.
• W2323041537 hasOpenAccess W2323041537 @default.
• W2323041537 hasPrimaryLocation W23230415371 @default.
• W2323041537 hasRelatedWork W1964078380 @default.
• W2323041537 hasRelatedWork W2011948815 @default.
• W2323041537 hasRelatedWork W2045868398 @default.
• W2323041537 hasRelatedWork W2047736491 @default.
• W2323041537 hasRelatedWork W2074416812 @default.
• W2323041537 hasRelatedWork W2092925654 @default.

• next