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• W2323085844 abstract "The first total synthesis of symplostatin 4, a marine cyanobacterium-derived natural product, is described. Notable features of the route include the efficient preparation of three key fragments and final assembly to the natural product via sequential imide and amide couplings. Symplostatin 4 was also demonstrated to possess significant antimalarial activity (ED50 of 74 nM against Plasmodium falciparum, strain 3D7)." @default.
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• W2323085844 date "2010-11-04" @default.
• W2323085844 modified "2023-09-29" @default.
• W2323085844 title "Total Synthesis and Antimalarial Activity of Symplostatin 4" @default.
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• W2323085844 doi "https://doi.org/10.1021/ol1024663" @default.
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