FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323092155> ?p ?o ?g. }

• W2323092155 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCCurcumin, a phytochemical in turmeric, has been studied as a potential anticancer drug targeting multiple signaling molecules. However, the role of Src and Ras signaling pathways in curcumin sensitivity remains unknown. We investigated therefore the molecular mechanism of anti-proliferative and apoptosis-inducing activities of curcumin in HAG-1 human gallbladder adenocarcinoma cells transfected with either activated Src (HAG/src3-1) or Ras (HAG/ras5-1). Effects of curcumin on proliferation, apoptosis, cell cycle perturbation, and signal proteins for survival, proliferation, and apoptosis were evaluated by WST-1 assay, FACS analyses and Western blotting. Activation of either Src or Ras did not confer resistance to curcumin compared to HAG/neo3-5 vehicle-transfected cells, producing similar IC50 concentrations of curcumin among these 3 cell lines. Upon treatment with curcumin, constitutive activities of Erk1/2 were enhanced, but those of Akt were significantly inhibited in these three cell lines, with subsequent reductions of activities of downstream mTOR and S6K1. The sub-G0/G1 apoptotic cell populations were substantially increased in all cell lines with demonstrable cleavage of PARP, but this increase was most prominent in Src-activated cells. Reduced expression and phosphorylation of Bcl-2 and enhanced expression of Bax were demonstrated to have a causative role for the curcumin-induced apoptosis in Src-driven, but not Ras-driven cells. By contrast, drastic increases of the proportion of cells in a G2/M phase were seen in Ras-activated cells, suggesting a potential role of Ras/Erk1/2 activation in curcumin-induced G2/M cell cycle arrest. These data indicate that curcumin-induced growth declines would be mediated mainly by G2/M arrest of the cell cycle in Ras-driven cells but by apoptosis induction in Src-driven cells. Taken together, the results indicate that curcumin exhibits differential activities against apoptosis and cell cycle progression, depending on activation mechanisms of signal transduction, and that curcumin can overcome Src- and Ras-driven activation of downstream signaling pathways, thus providing evidence of potential application of curcumin for the treatment of human cancers with activated Src or Ras.Citation Format: Misaki Ono, Takako Higuchi, Mikako Takeshima, Chen Chen, Shuji Nakano. Differential anti-tumor activities of curcumin against apoptosis and cell Cycle progression in Src- and Ras-activated human gallbladder carcinoma cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2575. doi:10.1158/1538-7445.AM2013-2575" @default.
• W2323092155 created "2016-06-24" @default.
• W2323092155 creator A5012438079 @default.
• W2323092155 creator A5017008708 @default.
• W2323092155 creator A5032697401 @default.
• W2323092155 creator A5050062079 @default.
• W2323092155 creator A5063253432 @default.
• W2323092155 date "2013-04-15" @default.
• W2323092155 modified "2023-09-27" @default.
• W2323092155 title "Abstract 2575: Differential anti-tumor activities of curcumin against apoptosis and cell Cycle progression in Src- and Ras-activated human gallbladder carcinoma cells." @default.
• W2323092155 doi "https://doi.org/10.1158/1538-7445.am2013-2575" @default.
• W2323092155 hasPublicationYear "2013" @default.
• W2323092155 type Work @default.
• W2323092155 sameAs 2323092155 @default.
• W2323092155 citedByCount "0" @default.
• W2323092155 crossrefType "proceedings-article" @default.
• W2323092155 hasAuthorship W2323092155A5012438079 @default.
• W2323092155 hasAuthorship W2323092155A5017008708 @default.
• W2323092155 hasAuthorship W2323092155A5032697401 @default.
• W2323092155 hasAuthorship W2323092155A5050062079 @default.
• W2323092155 hasAuthorship W2323092155A5063253432 @default.
• W2323092155 hasConcept C105696609 @default.
• W2323092155 hasConcept C108636557 @default.
• W2323092155 hasConcept C185592680 @default.
• W2323092155 hasConcept C190283241 @default.
• W2323092155 hasConcept C2778250585 @default.
• W2323092155 hasConcept C29537977 @default.
• W2323092155 hasConcept C502942594 @default.
• W2323092155 hasConcept C54009773 @default.
• W2323092155 hasConcept C54355233 @default.
• W2323092155 hasConcept C55493867 @default.
• W2323092155 hasConcept C62112901 @default.
• W2323092155 hasConcept C62478195 @default.
• W2323092155 hasConcept C75217442 @default.
• W2323092155 hasConcept C81885089 @default.
• W2323092155 hasConcept C86554907 @default.
• W2323092155 hasConcept C86803240 @default.
• W2323092155 hasConcept C95444343 @default.
• W2323092155 hasConcept C98274493 @default.
• W2323092155 hasConceptScore W2323092155C105696609 @default.
• W2323092155 hasConceptScore W2323092155C108636557 @default.
• W2323092155 hasConceptScore W2323092155C185592680 @default.
• W2323092155 hasConceptScore W2323092155C190283241 @default.
• W2323092155 hasConceptScore W2323092155C2778250585 @default.
• W2323092155 hasConceptScore W2323092155C29537977 @default.
• W2323092155 hasConceptScore W2323092155C502942594 @default.
• W2323092155 hasConceptScore W2323092155C54009773 @default.
• W2323092155 hasConceptScore W2323092155C54355233 @default.
• W2323092155 hasConceptScore W2323092155C55493867 @default.
• W2323092155 hasConceptScore W2323092155C62112901 @default.
• W2323092155 hasConceptScore W2323092155C62478195 @default.
• W2323092155 hasConceptScore W2323092155C75217442 @default.
• W2323092155 hasConceptScore W2323092155C81885089 @default.
• W2323092155 hasConceptScore W2323092155C86554907 @default.
• W2323092155 hasConceptScore W2323092155C86803240 @default.
• W2323092155 hasConceptScore W2323092155C95444343 @default.
• W2323092155 hasConceptScore W2323092155C98274493 @default.
• W2323092155 hasLocation W23230921551 @default.
• W2323092155 hasOpenAccess W2323092155 @default.
• W2323092155 hasPrimaryLocation W23230921551 @default.
• W2323092155 hasRelatedWork W1918343326 @default.
• W2323092155 hasRelatedWork W1957155456 @default.
• W2323092155 hasRelatedWork W1975690861 @default.
• W2323092155 hasRelatedWork W2015309828 @default.
• W2323092155 hasRelatedWork W2043371357 @default.
• W2323092155 hasRelatedWork W2052369675 @default.
• W2323092155 hasRelatedWork W2085982187 @default.
• W2323092155 hasRelatedWork W2091203908 @default.
• W2323092155 hasRelatedWork W2094863669 @default.
• W2323092155 hasRelatedWork W2105164602 @default.
• W2323092155 hasRelatedWork W2158313978 @default.
• W2323092155 hasRelatedWork W2180507727 @default.
• W2323092155 hasRelatedWork W2285041759 @default.
• W2323092155 hasRelatedWork W2471685804 @default.
• W2323092155 hasRelatedWork W2472904797 @default.
• W2323092155 hasRelatedWork W2550949056 @default.
• W2323092155 hasRelatedWork W2793413224 @default.
• W2323092155 hasRelatedWork W3151434922 @default.
• W2323092155 hasRelatedWork W3164225852 @default.
• W2323092155 hasRelatedWork W426734051 @default.
• W2323092155 isParatext "false" @default.
• W2323092155 isRetracted "false" @default.
• W2323092155 magId "2323092155" @default.
• W2323092155 workType "article" @default.