FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323146593> ?p ?o ?g. }

• W2323146593 endingPage "24" @default.
• W2323146593 startingPage "17" @default.
• W2323146593 abstract "In Brief Idiopathic pulmonary fibrosis (IPF), with the histologic correlate of usual interstitial pneumonia, has an almost uniformly poor prognosis when compared with other idiopathic interstitial pneumonias. To date, therapeutic attempts, including corticosteroids and immunosuppressive agents, have focused on targeting the inflammatory component of the disease with limited success; only 10% of patients derive significant physiological benefit with this approach. Systematic evaluation of different therapeutic regimens has previously been hampered by a nonstandardized approach to trial design, diagnostic criteria, and treatment protocols. The pathogenesis of IPF has been classically described as a predominantly inflammatory process, in response to an environmental trigger in a genetically susceptible individual, with subsequent fibrogenesis. The relative lack of efficacy of anti-inflammatory therapy has prompted an evolution in our understanding of pathogenesis, with focus on epithelial injury, dysregulation of wound healing, and the fibroblastic focus. Recent therapeutic approaches include antifibrogenic agents such as interferon-γ, pirfenidone, and bosentan, and antioxidant therapies such as N-acetylcysteine, whereas many others are at preliminary stages of laboratory and clinical evaluation. In light of recent reclassification of the idiopathic interstitial pneumonias, this review explores the evolving theories of pathogenesis of IPF, the evidence supporting traditional anti-inflammatory and recent antifibrotic and antioxidant therapies, the idiosyncrasies of past study design, and the need for standardized treatment guidelines. At present, the course of IPF remains relentlessly progressive. The development of new therapeutic approaches, recruitment into well-constructed large multicenter trials, and ongoing laboratory and clinical research brings renewed enthusiasm to this devastating disease. Idiopathic pulmonary fibrosis carries a poor prognosis despite current anti-inflammatory and immunosuppressive therapies. This review explores the evolving theories of pathogenesis, the evidence supporting traditional anti-inflammatory and recent antifibrotic and antioxidant therapies, the idiosyncrasies of past study design, and the need for standardized treatment guidelines." @default.
• W2323146593 created "2016-06-24" @default.
• W2323146593 creator A5042561953 @default.
• W2323146593 creator A5074166442 @default.
• W2323146593 date "2006-01-01" @default.
• W2323146593 modified "2023-09-28" @default.
• W2323146593 title "Treatment of Idiopathic Pulmonary Fibrosis" @default.
• W2323146593 cites W1862182724 @default.
• W2323146593 cites W1902906520 @default.
• W2323146593 cites W1965635977 @default.
• W2323146593 cites W1971697725 @default.
• W2323146593 cites W1979802375 @default.
• W2323146593 cites W1990383677 @default.
• W2323146593 cites W1995444375 @default.
• W2323146593 cites W2005543326 @default.
• W2323146593 cites W2006192600 @default.
• W2323146593 cites W2013414651 @default.
• W2323146593 cites W2015964736 @default.
• W2323146593 cites W2018809578 @default.
• W2323146593 cites W2023437751 @default.
• W2323146593 cites W2025441604 @default.
• W2323146593 cites W2026124727 @default.
• W2323146593 cites W2041614284 @default.
• W2323146593 cites W2050754815 @default.
• W2323146593 cites W2063195524 @default.
• W2323146593 cites W2068999024 @default.
• W2323146593 cites W2086868638 @default.
• W2323146593 cites W2095309945 @default.
• W2323146593 cites W2102838725 @default.
• W2323146593 cites W2108226118 @default.
• W2323146593 cites W2112949206 @default.
• W2323146593 cites W2121910720 @default.
• W2323146593 cites W2124068388 @default.
• W2323146593 cites W2125322938 @default.
• W2323146593 cites W2134540044 @default.
• W2323146593 cites W2139890009 @default.
• W2323146593 cites W2142941142 @default.
• W2323146593 cites W2149746349 @default.
• W2323146593 cites W2159845637 @default.
• W2323146593 cites W2163147529 @default.
• W2323146593 cites W2163671238 @default.
• W2323146593 cites W2171551945 @default.
• W2323146593 cites W2231700130 @default.
• W2323146593 cites W2315878550 @default.
• W2323146593 cites W2416914730 @default.
• W2323146593 cites W2614365993 @default.
• W2323146593 cites W2626588662 @default.
• W2323146593 doi "https://doi.org/10.1097/01.cpm.0000198144.90287.1f" @default.
• W2323146593 hasPublicationYear "2006" @default.
• W2323146593 type Work @default.
• W2323146593 sameAs 2323146593 @default.
• W2323146593 citedByCount "0" @default.
• W2323146593 crossrefType "journal-article" @default.
• W2323146593 hasAuthorship W2323146593A5042561953 @default.
• W2323146593 hasAuthorship W2323146593A5074166442 @default.
• W2323146593 hasConcept C126322002 @default.
• W2323146593 hasConcept C142724271 @default.
• W2323146593 hasConcept C177713679 @default.
• W2323146593 hasConcept C203014093 @default.
• W2323146593 hasConcept C2777405647 @default.
• W2323146593 hasConcept C2777714996 @default.
• W2323146593 hasConcept C2778341716 @default.
• W2323146593 hasConcept C2779134260 @default.
• W2323146593 hasConcept C2779832356 @default.
• W2323146593 hasConcept C2780559512 @default.
• W2323146593 hasConcept C2780942790 @default.
• W2323146593 hasConcept C2781244666 @default.
• W2323146593 hasConcept C2781378642 @default.
• W2323146593 hasConcept C535046627 @default.
• W2323146593 hasConcept C71924100 @default.
• W2323146593 hasConceptScore W2323146593C126322002 @default.
• W2323146593 hasConceptScore W2323146593C142724271 @default.
• W2323146593 hasConceptScore W2323146593C177713679 @default.
• W2323146593 hasConceptScore W2323146593C203014093 @default.
• W2323146593 hasConceptScore W2323146593C2777405647 @default.
• W2323146593 hasConceptScore W2323146593C2777714996 @default.
• W2323146593 hasConceptScore W2323146593C2778341716 @default.
• W2323146593 hasConceptScore W2323146593C2779134260 @default.
• W2323146593 hasConceptScore W2323146593C2779832356 @default.
• W2323146593 hasConceptScore W2323146593C2780559512 @default.
• W2323146593 hasConceptScore W2323146593C2780942790 @default.
• W2323146593 hasConceptScore W2323146593C2781244666 @default.
• W2323146593 hasConceptScore W2323146593C2781378642 @default.
• W2323146593 hasConceptScore W2323146593C535046627 @default.
• W2323146593 hasConceptScore W2323146593C71924100 @default.
• W2323146593 hasIssue "1" @default.
• W2323146593 hasLocation W23231465931 @default.
• W2323146593 hasOpenAccess W2323146593 @default.
• W2323146593 hasPrimaryLocation W23231465931 @default.
• W2323146593 hasRelatedWork W1837900736 @default.
• W2323146593 hasRelatedWork W1972038951 @default.
• W2323146593 hasRelatedWork W1973607804 @default.
• W2323146593 hasRelatedWork W2033071947 @default.
• W2323146593 hasRelatedWork W2081906687 @default.
• W2323146593 hasRelatedWork W2394846390 @default.
• W2323146593 hasRelatedWork W2556425970 @default.
• W2323146593 hasRelatedWork W2769810301 @default.
• W2323146593 hasRelatedWork W2945509420 @default.

• next