Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323167715> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2323167715 endingPage "S56" @default.
- W2323167715 startingPage "S56" @default.
- W2323167715 abstract "Vitamin D deficiency is common, and is associated with increased risk of osteoporosis and, increasingly, is shown to have association with many other illnesses. There are many ways to measure vitamin D, but all can suffer from precision and bias. Recently, Roche removed its Elecsys Vitamin D3 (25OH) electrochemilu-minescence immunoassay (ECLIA) from the market, citing deteriorating traceability to the reference method. We investigated the performance of two formulations of the Roche immunoassay against the reference method (liquid chromatography tandem mass spectrometry). A set of samples was assayed for vitamin D using the polyclonal formulation of the Elecsys electrochemiluminescence immunoas-say, and the monoclonal immunoassay. A subset of samples was assayed for vitamin D3 using LCMSMS. The correlation between the monoclonal formulation of ECLIA and LCMSMS was: ECLIA (monoclonal)=14; 0.31 LCMSMS + 23, r<sup>2</sup>=14; 0.27. The correlation between the monoclonal and polyclonal formulations of the ECLIA was: ECLIA (monoclonal)=14; 0.93 ECLIA (polyclonal) – 3, r<sup>2</sup>=14; 0.60. At the time of its removal from market, the Roche Elecsys vitamin D3 (25OH) electrochemiluminescence immunoassay had unacceptable performance, markedly under-reporting vitamin D levels. The bias likely preceded the introduction of the monoclonal formulation of the immunoassay." @default.
- W2323167715 created "2016-06-24" @default.
- W2323167715 creator A5008100140 @default.
- W2323167715 creator A5071509205 @default.
- W2323167715 date "2011-01-01" @default.
- W2323167715 modified "2023-09-27" @default.
- W2323167715 title "Overreporting of vitamin D levels by the roche elecsys vitamin D3 (25OH) method" @default.
- W2323167715 doi "https://doi.org/10.1016/s0031-3025(16)33195-6" @default.
- W2323167715 hasPublicationYear "2011" @default.
- W2323167715 type Work @default.
- W2323167715 sameAs 2323167715 @default.
- W2323167715 citedByCount "0" @default.
- W2323167715 crossrefType "journal-article" @default.
- W2323167715 hasAuthorship W2323167715A5008100140 @default.
- W2323167715 hasAuthorship W2323167715A5071509205 @default.
- W2323167715 hasConcept C124490489 @default.
- W2323167715 hasConcept C126322002 @default.
- W2323167715 hasConcept C159654299 @default.
- W2323167715 hasConcept C163864487 @default.
- W2323167715 hasConcept C185592680 @default.
- W2323167715 hasConcept C203014093 @default.
- W2323167715 hasConcept C2780420688 @default.
- W2323167715 hasConcept C2909597000 @default.
- W2323167715 hasConcept C43617362 @default.
- W2323167715 hasConcept C542903549 @default.
- W2323167715 hasConcept C71924100 @default.
- W2323167715 hasConcept C956191 @default.
- W2323167715 hasConceptScore W2323167715C124490489 @default.
- W2323167715 hasConceptScore W2323167715C126322002 @default.
- W2323167715 hasConceptScore W2323167715C159654299 @default.
- W2323167715 hasConceptScore W2323167715C163864487 @default.
- W2323167715 hasConceptScore W2323167715C185592680 @default.
- W2323167715 hasConceptScore W2323167715C203014093 @default.
- W2323167715 hasConceptScore W2323167715C2780420688 @default.
- W2323167715 hasConceptScore W2323167715C2909597000 @default.
- W2323167715 hasConceptScore W2323167715C43617362 @default.
- W2323167715 hasConceptScore W2323167715C542903549 @default.
- W2323167715 hasConceptScore W2323167715C71924100 @default.
- W2323167715 hasConceptScore W2323167715C956191 @default.
- W2323167715 hasLocation W23231677151 @default.
- W2323167715 hasOpenAccess W2323167715 @default.
- W2323167715 hasPrimaryLocation W23231677151 @default.
- W2323167715 hasRelatedWork W2025158762 @default.
- W2323167715 hasRelatedWork W2030675209 @default.
- W2323167715 hasRelatedWork W2031151107 @default.
- W2323167715 hasRelatedWork W2038300744 @default.
- W2323167715 hasRelatedWork W2076989562 @default.
- W2323167715 hasRelatedWork W2116596056 @default.
- W2323167715 hasRelatedWork W2157533994 @default.
- W2323167715 hasRelatedWork W2306637629 @default.
- W2323167715 hasRelatedWork W2323167715 @default.
- W2323167715 hasRelatedWork W2413337300 @default.
- W2323167715 hasVolume "43" @default.
- W2323167715 isParatext "false" @default.
- W2323167715 isRetracted "false" @default.
- W2323167715 magId "2323167715" @default.
- W2323167715 workType "article" @default.